Lopez-Aldazabal Victoria, Mirabella Nicole, Biller David S
MedVet Chicago, Chicago, Illinois, USA.
Vet Med Sci. 2025 Sep;11(5):e70574. doi: 10.1002/vms3.70574.
A 5-year-old neutered male domestic medium-hair cat was referred to the internal medicine department with upper respiratory signs and limb pain. Computed tomography (CT) revealed diffuse osteosclerosis, showing severe osseous thickening of the nasal turbinates and near-occlusion of the nasal passages. No new or healed fractures were observed. Additional diagnostic tests revealed no infectious or neoplastic causes. The cat was treated supportively for pain and nasal inflammation. One year after the diagnosis, the cat was described as having an acceptable quality of life at home, despite ongoing clinical signs of nasal congestion.
Chronic upper airway congestion is a common presenting complaint in feline patients. This report describes the imaging findings in a cat in which upper airway signs were due in part to systemic bone pathology. Previous reports suggest that the most common causes of chronic nasal congestion are acquired conditions with poor prognosis, such as lymphoplasmacytic rhinitis, neoplasia, or fungal infection. Diseases that cause diffuse osteosclerosis in cats are poorly understood. This report describes a case of diffuse osteosclerosis in a young cat with no other known comorbidities. The clinical picture is similar to descriptions of an osteosclerotic bone disorder in humans commonly referred to as autosomal dominant osteopetrosis type 1. Since no targeted treatments are available to reverse the osseous changes, the patient was treated supportively with pain management and corticosteroids. Recent developments in our understanding and treatment of similar human diseases may guide future advances in veterinary medicine.
一只5岁已绝育的雄性家养中毛猫因上呼吸道症状和肢体疼痛被转诊至内科。计算机断层扫描（CT）显示弥漫性骨硬化，表现为鼻甲骨严重骨质增厚以及鼻道近乎闭塞。未观察到新的或愈合的骨折。进一步的诊断检查未发现感染性或肿瘤性病因。该猫接受了疼痛和鼻炎症的支持性治疗。诊断一年后，尽管仍有鼻充血的临床症状，但据描述这只猫在家中的生活质量尚可。
慢性上呼吸道充血是猫科动物患者常见的就诊主诉。本报告描述了一只猫的影像学表现，其气道症状部分归因于全身性骨骼病变。先前的报告表明，慢性鼻充血最常见的病因是预后不良的后天性疾病，如淋巴细胞性浆细胞性鼻炎、肿瘤或真菌感染。导致猫弥漫性骨硬化的疾病目前了解甚少。本报告描述了一只无其他已知合并症的幼猫的弥漫性骨硬化病例。临床症状与人类一种通常称为常染色体显性1型骨硬化症的骨硬化性骨病的描述相似。由于尚无针对性治疗方法可逆转骨质变化，该患者接受了疼痛管理和皮质类固醇的支持性治疗。我们对类似人类疾病的理解和治疗方面的最新进展可能会为兽医学的未来发展提供指导。
