Ryu Jihye, Hwang Dae-Seok
Department of Oral and Maxillofacial Surgery, Pusan National University Dental Hospital, Yangsan, Korea, Republic of.
Maxillofac Plast Reconstr Surg. 2025 Aug 20;47(1):22. doi: 10.1186/s40902-025-00477-6.
This study aims to evaluate the outcomes of secondary alveolar bone grafting in patients with cleft lip and palate by comparing the clinical effectiveness of autologous bone grafts and xenogeneic graft materials. The objective is to provide evidence-based insight into the comparative efficacy of these grafting approaches.
A systematic search of the literature published between January 2004 and January 2023 identified 606 studies. Following a series of screening processes, five studies met the inclusion criteria, including only two randomized controlled trials (RCTs). The selected studies specifically evaluated xenogeneic bone graft materials derived from bovine sources, with allograft materials excluded. The results demonstrated no statistically significant difference between autologous and xenograft grafts in terms of postoperative bone graft volume and height in patients with cleft lip and palate. These findings provide important insight into the comparative effectiveness of grafting materials used in secondary alveolar bone grafting.
In summary, the findings indicate that autologous and xenogeneic graft materials yield comparable outcomes in secondary alveolar bone grafting for patients with cleft lip and palate. These results may inform clinical decision-making and guide future research in optimizing grafting strategies.
本研究旨在通过比较自体骨移植和异种移植材料的临床效果，评估唇腭裂患者二期牙槽骨移植的结果。目的是为这些移植方法的比较疗效提供基于证据的见解。
对2004年1月至2023年1月发表的文献进行系统检索，共识别出606项研究。经过一系列筛选过程，有5项研究符合纳入标准，其中仅有2项随机对照试验（RCT）。所选研究专门评估了源自牛源的异种骨移植材料，排除了同种异体移植材料。结果表明，在唇腭裂患者中，自体移植和异种移植在术后骨移植体积和高度方面无统计学显著差异。这些发现为二期牙槽骨移植中使用的移植材料的比较有效性提供了重要见解。
总之，研究结果表明，自体和异种移植材料在唇腭裂患者二期牙槽骨移植中产生的结果相当。这些结果可能为临床决策提供参考，并指导未来优化移植策略的研究。
