Oliveira Jobson Lopes de, Nogueira Igor Albuquerque, Jucá Maurício Catunda Pinheiro, Eisele Afonso Rocha, Farias Luís Arthur Brasil Gadelha, Rangel Diana Arrais de Souza
Centro Universitário Christus, Faculdade de Medicina, Fortaleza, Ceará, Brazil.
Universidade Federal do Ceará, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, Fortaleza, Ceará, Brazil.
Rev Inst Med Trop Sao Paulo. 2025 Aug 18;67:e52. doi: 10.1590/S1678-9946202567052. eCollection 2025.
Behçet's disease (BD) is a chronic and multisystem disorder characterized by recurrent oral and genital ulcers, along with ocular, cutaneous, vascular, gastrointestinal, and neurologic manifestations. The etiology is thought to involve an autoimmune response triggered by infectious or environmental factors in genetically predisposed individuals. Mycobacterium tuberculosis has been proposed as a potential trigger for BD, although this association remains rarely reported. We show a compelling case of a patient with BD diagnostic criteria who subsequently developed mediastinal tuberculous lymphadenitis, which was initially suspected as disease activity. This case underscores the importance of considering tuberculosis in BD patients with new or worsening symptoms despite appropriate therapy.
白塞病（BD）是一种慢性多系统疾病，其特征为复发性口腔和生殖器溃疡，以及眼部、皮肤、血管、胃肠道和神经方面的表现。病因被认为涉及在遗传易感性个体中由感染或环境因素触发的自身免疫反应。尽管这种关联仍鲜有报道，但结核分枝杆菌已被提出作为BD的潜在触发因素。我们展示了一个令人信服的病例，一名符合BD诊断标准的患者随后发展为纵隔结核性淋巴结炎，最初被怀疑是疾病活动。该病例强调了在接受适当治疗后仍出现新症状或症状恶化的BD患者中考虑结核病的重要性。
