Shen Yan, Ma Haifen, Luo Dan, Cai Jianfei, Zou Jun, Bao Zhijun, Guan Jianlong
Division of Rheumatology, Huadong Hospital, Fudan University, Shanghai 200040, China.
Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China.
Open Med (Wars). 2020 Nov 21;16(1):14-22. doi: 10.1515/med-2021-0002. eCollection 2021.
The aim of this study is to examine the clinical features of patients with Behçet's disease (BD) in the presence or absence of latent tuberculosis infection (LTBI).
This was a retrospective study of 232 consecutive patients with active BD hospitalized between October 2012 and June 2017. LTBI was diagnosed based on the positive T-SPOT.TB assay, negative clinical, and imaging examinations.
Among the 232 patients, 68 (29.3%) had LTBI. The frequency, number, and scope of oral ulcers in the BD-LTBI group were significantly more serious than in the non-LTBI group (all < 0.05). Genital ulcers and eye involvement in the LTBI group were significantly higher than in the non-LTBI group (both < 0.01). No active TB was diagnosed during follow-up (median, 27.9 months; range, 3-58 months). The patients with LTBI had signs of liver damage compared with the non-LTBI group. In the LTBI group, the frequency of alanine transaminase >2.0, the upper limit of normal, was higher in the rifampicin subgroup compared with the non-rifampicin subgroup ( = 0.033).
Patients with BD and LTBI had worse clinical features than those with BD without LTBI. Rifampicin might be associated with the damage to liver in BD patients combined with latent TB.
本研究旨在探讨白塞病（BD）患者合并或不合并潜伏性结核感染（LTBI）时的临床特征。
这是一项对2012年10月至2017年6月期间连续住院的232例活动性BD患者进行的回顾性研究。LTBI根据T-SPOT.TB检测阳性、临床和影像学检查阴性来诊断。
在232例患者中，68例（29.3%）有LTBI。BD-LTBI组口腔溃疡的频率、数量和范围比非LTBI组明显更严重（均P<0.05）。LTBI组生殖器溃疡和眼部受累情况明显高于非LTBI组（均P<0.01）。随访期间未诊断出活动性结核（中位随访时间27.9个月；范围3 - 58个月）。与非LTBI组相比，LTBI组患者有肝损伤迹象。在LTBI组中，利福平亚组丙氨酸转氨酶>正常上限2.0倍的频率高于非利福平亚组（P = 0.033）。
BD合并LTBI的患者比不合并LTBI的BD患者临床特征更差。利福平可能与BD合并潜伏性结核患者的肝损伤有关。
