代谢综合征患者的健康生活方式与主要非传染性慢性病风险及死亡率

Healthy lifestyles and risk of major non-communicable chronic diseases and mortality in individuals with metabolic syndrome.

作者信息

Gao Xiang, Zheng Jiali, Liu Mengdan, Liu Chong, Wang Yixin, Li Yan, Chen Weihua, Li Xiaoguang, Wang Hui

机构信息

School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

J Nutr Health Aging. 2025 Aug 19;29(9):100654. doi: 10.1016/j.jnha.2025.100654.

DOI:10.1016/j.jnha.2025.100654

PMID:40834545

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12396011/

Abstract

OBJECTIVES

To assess the associations between lifestyle factors and the risk of non-communicable chronic diseases (NCDs) and mortality in individuals with metabolic syndrome (MS), and to evaluate population-attributable risk (PAR) from multiple lifestyle factors.

METHODS

The study included 49,891 MS individuals from the UK Biobank. Seven lifestyle factors (smoking, diet, physical activity, sedentary behavior, sleep duration, psychological stress, and social contact status) were assessed using both unweighted and weighted lifestyle scores. Cox proportional hazards model was used to analyze the associations between lifestyle factors and major NCDs (diabetes, cardiovascular disease [CVD], chronic obstructive pulmonary disease [COPD], chronic kidney disease [CKD], and cancer) and all-cause mortality.

RESULTS

During a median follow-up of 11.0 years, 19,435 major NCDs and 3,578 deaths were recorded. Higher adherence to healthy lifestyle factors, assessed by both unweighted and weighted scores, was significantly associated with lower risks of major NCDs and all-cause mortality. Compared with participants having 0-3 healthy lifestyle factors (unweighted score), those with 6-7 factors had 28% (HR = 0.72, 95% CI: 0.69-0.75) lower risk of major NCDs and 39% (HR = 0.61, 95% CI: 0.55-0.69) lower risk of mortality. Correspondingly, using the weighted lifestyle score, the very healthy group showed a 27% (HR = 0.73, 95% CI: 0.70-0.76) lower risk of major NCDs and a 40% (HR = 0.60, 95% CI: 0.54-0.66) lower risk of mortality compared with the very unhealthy group. The PARs associated with all 7 healthy lifestyle factors were 20.72% and 26.93% for major NCDs and all-cause mortality, respectively.

CONCLUSIONS

The adoption of multiple healthy behaviors significantly reduces the risk of NCDs and mortality in MS patients, highlighting the need for more comprehensive lifestyle interventions targeted at this group with metabolic impairments.

摘要

目的

评估生活方式因素与代谢综合征（MS）个体的非传染性慢性病（NCDs）风险及死亡率之间的关联，并评估多种生活方式因素所致的人群归因风险（PAR）。

方法

该研究纳入了英国生物银行的49891名MS个体。使用未加权和加权生活方式评分评估了七种生活方式因素（吸烟、饮食、身体活动、久坐行为、睡眠时间、心理压力和社会接触状况）。采用Cox比例风险模型分析生活方式因素与主要NCDs（糖尿病、心血管疾病[CVD]、慢性阻塞性肺疾病[COPD]、慢性肾脏病[CKD]和癌症）及全因死亡率之间的关联。

结果

在中位随访11.0年期间，记录了19435例主要NCDs和3578例死亡。通过未加权和加权评分评估，更高的健康生活方式因素依从性与更低的主要NCDs风险和全因死亡率显著相关。与具有0 - 3种健康生活方式因素（未加权评分）的参与者相比，具有6 - 7种因素的参与者患主要NCDs的风险降低28%（HR = 0.72，95%CI：0.69 - 0.75），死亡风险降低39%（HR = 0.61，95%CI：0.55 - 0.69）。相应地，使用加权生活方式评分，与极不健康组相比，非常健康组患主要NCDs的风险降低27%（HR = 0.73，95%CI：0.70 - 0.76），死亡风险降低40%（HR = 0.60，95%CI：0.54 - 0.66）。与所有7种健康生活方式因素相关的PARs，主要NCDs为20.72%，全因死亡率为26.93%。