He Guiying, Zhang Jiatong, Liu Xinyue, Qiu Zhengjie, Yan Mengqing, Zhang Mingxuan, Wu Dongyang, Liu Lipei, Ding Cheng, Chen Xing
Stomatology Center, Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
School of Stomatology, Hangzhou Normal University, Hangzhou, China.
Sci Rep. 2025 Aug 20;15(1):30536. doi: 10.1038/s41598-025-14664-y.
The Weight-adjusted Waist Index (WWI) is a novel anthropometric indicator for assessing obesity. Given the well-established association between obesity and periodontitis, this cross-sectional clinical study aimed to investigate the relationship between WWI and severe periodontitis while evaluating its potential as a simple predictive marker for periodontitis. The study analyzed periodontal examination data and WWI measurements from participants in the 2009-2014 National Health and Nutrition Examination Survey (NHANES), employing weighted logistic regression, smoothed curve fitting, and subgroup analyses. Among the 10,307 eligible participants, results demonstrated a significant positive correlation between WWI and the prevalence of stage III/IV periodontitis. After comprehensive adjustment for all confounding factors, each 1-unit increase in WWI was associated with a 1.19-fold higher risk of stage III/IV periodontitis (OR = 1.19, 95% CI 1.06-1.32, P = 0.007977). Subgroup analysis revealed that this association showed statistically significant variation only in the hypertension subgroup, indicating that the WWI-severe periodontitis relationship is particularly applicable to non-hypertensive individuals. These findings confirm that WWI can serve as a novel obesity-based predictive indicator for severe periodontitis.
体重调整腰围指数（WWI）是一种用于评估肥胖的新型人体测量指标。鉴于肥胖与牙周炎之间已确立的关联，这项横断面临床研究旨在调查WWI与重度牙周炎之间的关系，同时评估其作为牙周炎简单预测指标的潜力。该研究分析了2009 - 2014年国家健康与营养检查调查（NHANES）参与者的牙周检查数据和WWI测量值，采用加权逻辑回归、平滑曲线拟合和亚组分析。在10307名符合条件的参与者中，结果表明WWI与III/IV期牙周炎患病率之间存在显著正相关。在对所有混杂因素进行全面调整后，WWI每增加1个单位，患III/IV期牙周炎的风险就会增加1.19倍（OR = 1.19，95% CI 1.06 - 1.32，P = 0.007977）。亚组分析显示，这种关联仅在高血压亚组中存在统计学上的显著差异，表明WWI与重度牙周炎的关系特别适用于非高血压个体。这些发现证实，WWI可作为一种基于肥胖的新型重度牙周炎预测指标。
