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Progressive T cell defects correlate with disease outcome in high-count monoclonal B-cell lymphocytosis.

作者信息

Parikh Sameer A, Ioannou Nikolaos, Ramsay Alan G, Boysen Justin C, Kenderian Saad S, Rabe Kari G, Sinha Sutapa, Braggio Esteban, Medina Kay L, Slager Susan L, Shanafelt Tait D, Kay Neil E

机构信息

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.

出版信息

Leukemia. 2025 Aug 20. doi: 10.1038/s41375-025-02689-1.

DOI:10.1038/s41375-025-02689-1
PMID:40836016
Abstract
摘要

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1
Progressive T cell defects correlate with disease outcome in high-count monoclonal B-cell lymphocytosis.进展性T细胞缺陷与高计数单克隆B细胞淋巴细胞增多症的疾病预后相关。
Leukemia. 2025 Aug 20. doi: 10.1038/s41375-025-02689-1.
2
Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome.低计数单克隆 B 细胞淋巴细胞增多症在随访 7 年后仍持续存在，并与较差的预后相关。
Haematologica. 2018 Jul;103(7):1198-1208. doi: 10.3324/haematol.2017.183954. Epub 2018 Mar 22.
3
Host virus and pneumococcus-specific immune responses in high-count monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia: implications for disease progression.高计数单克隆B细胞淋巴细胞增多症和慢性淋巴细胞白血病中的宿主病毒及肺炎球菌特异性免疫反应：对疾病进展的影响
Haematologica. 2017 Jul;102(7):1238-1246. doi: 10.3324/haematol.2016.159012. Epub 2017 Apr 6.
4
Comparison of microRNA expression in high-count monoclonal B-cell lymphocytosis and Binet A chronic lymphocytic leukemia.高计数单克隆B淋巴细胞增多症与Binet A期慢性淋巴细胞白血病中微小RNA表达的比较。
Rev Bras Hematol Hemoter. 2017 Jul-Sep;39(3):237-243. doi: 10.1016/j.bjhh.2017.03.006. Epub 2017 Apr 22.
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Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia.单克隆B细胞淋巴细胞增多症与慢性淋巴细胞白血病
N Engl J Med. 2008 Aug 7;359(6):575-83. doi: 10.1056/NEJMoa075290.
6
The role of imaging studies in predicting time to first treatment and overall survival in high-count monoclonal B-cell lymphocytosis.影像学研究在预测高计数单克隆B细胞淋巴细胞增多症首次治疗时间和总生存期方面的作用。
Br J Haematol. 2025 Jul 15. doi: 10.1111/bjh.70009.
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Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach?单克隆 B 细胞淋巴增生症：老年患者是否需要特殊治疗方法？
Eur J Intern Med. 2018 Dec;58:2-6. doi: 10.1016/j.ejim.2018.09.006. Epub 2018 Sep 26.
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Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases.散发性（非家族性）慢性淋巴细胞白血病家族成员中的单克隆B细胞淋巴细胞增多症会随时间持续存在，但不会进展为慢性B细胞淋巴增殖性疾病。
Rev Bras Hematol Hemoter. 2015 Sep-Oct;37(5):292-5. doi: 10.1016/j.bjhh.2015.05.006. Epub 2015 Jun 30.
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Incidence of chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis using the 2008 guidelines.采用2008年指南诊断慢性淋巴细胞白血病和高计数单克隆B细胞淋巴细胞增多症的发病率
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Machine Learning Model Predicts Abnormal Lymphocytosis Associated With Chronic Lymphocytic Leukemia.机器学习模型可预测与慢性淋巴细胞白血病相关的异常淋巴细胞增多。
JCO Clin Cancer Inform. 2025 Jun;9:e2400197. doi: 10.1200/CCI-24-00197. Epub 2025 Jun 24.

本文引用的文献

1
Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis.肿瘤突变负荷可预测高计数单克隆 B 细胞淋巴增生症进展为治疗。
Blood Adv. 2024 May 14;8(9):2118-2129. doi: 10.1182/bloodadvances.2023012242.
2
Ibrutinib-based therapy reinvigorates CD8+ T cells compared to chemoimmunotherapy: immune monitoring from the E1912 trial.伊布替尼治疗方案与化疗免疫治疗相比能更有效地激活 CD8+T 细胞：E1912 试验的免疫监测结果。
Blood. 2024 Jan 4;143(1):57-63. doi: 10.1182/blood.2023020554.
3
Progression and survival of MBL: a screening study of 10 139 individuals.
MBL 的进展和生存情况：一项针对 10139 人的筛查研究。
Blood. 2022 Oct 13;140(15):1702-1709. doi: 10.1182/blood.2022016279.
4
Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.多基因风险评分与白种人单克隆B细胞淋巴细胞增多症风险以及非裔美国人慢性淋巴细胞白血病（CLL）风险
Leukemia. 2022 Jan;36(1):119-125. doi: 10.1038/s41375-021-01344-9. Epub 2021 Jul 20.
5
The CLL International Prognostic Index predicts outcomes in monoclonal B-cell lymphocytosis and Rai 0 CLL.CLL 国际预后指数可预测单克隆 B 细胞淋巴增生和 Rai 0 期 CLL 的结果。
Blood. 2021 Jul 15;138(2):149-159. doi: 10.1182/blood.2020009813.
6
Monoclonal B-cell lymphocytosis and hypogammaglobulinaemia.单克隆B细胞淋巴细胞增多症和低丙种球蛋白血症。
Br J Haematol. 2016 Apr;173(2):316-7. doi: 10.1111/bjh.13585. Epub 2015 Jul 20.
7
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.慢性淋巴细胞白血病（CLL）患者的 T 细胞表现出 T 细胞耗竭的特征，但保留细胞因子产生的能力。
Blood. 2013 Feb 28;121(9):1612-21. doi: 10.1182/blood-2012-09-457531. Epub 2012 Dec 17.
8
Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): a cohort study of newly diagnosed cases compared to controls.临床单克隆 B 细胞淋巴细胞增多症（MBL）患者的感染并发症：与对照相比，新诊断病例的队列研究。
Leukemia. 2013 Jan;27(1):136-41. doi: 10.1038/leu.2012.187. Epub 2012 Jul 11.
9
Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management.单克隆 B 细胞淋巴增生症（MBL）：生物学、自然史和临床管理。
Leukemia. 2010 Mar;24(3):512-20. doi: 10.1038/leu.2009.287. Epub 2010 Jan 21.
10
Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia.单克隆B细胞淋巴细胞增多症与慢性淋巴细胞白血病
N Engl J Med. 2008 Aug 7;359(6):575-83. doi: 10.1056/NEJMoa075290.