Han L Y, Chang T S, Hwang W Y
Ann Plast Surg. 1985 Oct;15(4):303-12. doi: 10.1097/00000637-198510000-00006.
Experimental studies on chronic lymphedema of the extremities were performed using dogs, and an improved technique after the method of Danese in the preparation of chronic limb lymphedema is described. The incidence of chronic lymphedema in this model was 81.8%, whereas with Danese's method, it was only 66.7%. In addition, the measurement of lymphatic and venous pressure was studied in experimental animals. In the normal limb, the lymphatic pressure was always lower than the venous pressure, while in the chronic lymphedematous limb, the lymphatic pressure was higher than the venous pressure. Thus, after a lymphaticovenous anastomosis, a pressure gradient reversal exists between the two sides of the anastomosis. Although the high lymphatic pressure gradually dropped as the anastomosis became patent, ultimately the venous pressure was often higher than the lymphatic pressure. A venous back flow can be ensured by the anastomosis and the resulting thrombosis, which obstructs the lymphaticovenous anastomosis, is inevitable.
利用犬进行了四肢慢性淋巴水肿的实验研究，并描述了一种在丹内塞方法基础上改进的制备慢性肢体淋巴水肿的技术。该模型中慢性淋巴水肿的发生率为81.8%，而采用丹内塞方法时仅为66.7%。此外，还对实验动物的淋巴管和静脉压力进行了测量。在正常肢体中，淋巴管压力始终低于静脉压力，而在慢性淋巴水肿肢体中，淋巴管压力高于静脉压力。因此，在进行淋巴管静脉吻合术后，吻合口两侧存在压力梯度逆转。尽管随着吻合口通畅，高淋巴管压力逐渐下降，但最终静脉压力往往高于淋巴管压力。通过吻合可以确保静脉回流，而吻合导致的血栓形成不可避免，血栓会阻塞淋巴管静脉吻合。
