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糖尿病患者的子宫内膜炎:基质辅助激光解吸电离飞行时间质谱在非宫内节育器相关病例中克服了诊断障碍。

endometritis in a diabetic patient: MALDI-TOF MS overcomes diagnostic barriers in a non-IUD-associated case.

作者信息

Liu Yan, Li Mei, Ding Yunyun, Gao Yong, Li Tuantuan, Wang Xiaowu

机构信息

Department of Clinical Laboratory, The Second People's Hospital of Fuyang City, Fuyang, China.

Fuyang Infection Disease Clinical College of Anhui Medical University, Anhui, China.

出版信息

Front Med (Lausanne). 2025 Aug 5;12:1593385. doi: 10.3389/fmed.2025.1593385. eCollection 2025.

DOI:10.3389/fmed.2025.1593385
PMID:40837572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361152/
Abstract

is a single-cell prokaryotic microorganism and a common component of the normal human oral flora. If it enters other parts and causes infection, it may lead to actinomycosis. We present the case of a 74-year-old female patient from Fuyang who developed bacterial endometritis due to . The bacterial culture of painless cervical dilation with drainage and curettage showed slow-growing, Gram-positive rods, which were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as . The patient was initially treated empirically with cefathiamidine and tinidazole for 3 days, with no improvement of symptoms. Subsequently, the treatment regimen was adjusted to intravenous infusion of amoxicillin and clavulanate potassium (1.2 g) every 8 h for 7 days. Resulted in significant alleviation of the patient's symptoms. Clinicians should be aware of other types of infections that may be caused by .

摘要

是一种单细胞原核微生物,是正常人类口腔菌群的常见组成部分。如果它进入身体其他部位并引起感染,可能会导致放线菌病。我们报告了一例来自阜阳的74岁女性患者,她因……患上了细菌性子宫内膜炎。无痛宫颈扩张引流刮宫术的细菌培养显示生长缓慢的革兰氏阳性杆菌,通过基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)鉴定为……。患者最初经验性地用头孢硫脒和替硝唑治疗3天,症状无改善。随后,治疗方案调整为每8小时静脉输注阿莫西林克拉维酸钾(1.2 g),共7天。这使患者症状明显缓解。临床医生应意识到……可能引起的其他类型感染。

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本文引用的文献

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Case report: A rare case of skin abscess caused by coinfection of and .病例报告:一种罕见的皮肤脓肿,由 和 混合感染引起。
Front Cell Infect Microbiol. 2024 Mar 27;14:1378197. doi: 10.3389/fcimb.2024.1378197. eCollection 2024.
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Prevalence of chronic endometritis in infertile women undergoing hysteroscopy and its association with intrauterine abnormalities: A Cross-Sectional study.宫腔镜检查不孕妇女慢性子宫内膜炎的患病率及其与宫腔内异常的关系:一项横断面研究。
JBRA Assist Reprod. 2024 Aug 26;28(3):430-434. doi: 10.5935/1518-0557.20240011.
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A Rare Case of Non-IUD-Related Chronic Endometritis caused by Actinomyces Bacteria in a Postmenopausal Woman: A Case Report.
绝经后妇女因放线菌引起的罕见非宫内节育器相关慢性子宫内膜炎病例报告
P R Health Sci J. 2022 Sep;41(3):165-167.
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Research update for the immune microenvironment of chronic endometritis.慢性子宫内膜炎免疫微环境研究进展。
J Reprod Immunol. 2022 Aug;152:103637. doi: 10.1016/j.jri.2022.103637. Epub 2022 May 11.
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Diagnosis of chronic endometritis: How many CD138 cells/HPF in endometrial stroma affect pregnancy outcome of infertile women?慢性子宫内膜炎的诊断:子宫内膜间质中每高倍视野CD138细胞数量对不孕女性妊娠结局有何影响?
Am J Reprod Immunol. 2021 May;85(5):e13369. doi: 10.1111/aji.13369. Epub 2020 Nov 24.
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Pelvic actinomycosis presenting as a single episode of postmenopausal bleeding in a 60-year-old woman whose intrauterine contraceptive device had been removed 10 years previously: A case report.60岁女性盆腔放线菌病表现为绝经后单次阴道出血,该患者10年前已取出宫内节育器:病例报告
Case Rep Womens Health. 2020 Oct 24;28:e00267. doi: 10.1016/j.crwh.2020.e00267. eCollection 2020 Oct.
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The Pathogenic Role of spp. and Related Organisms in Genitourinary Infections: Discoveries in the New, Modern Diagnostic Era.某些菌种及相关微生物在泌尿生殖系统感染中的致病作用:新的现代诊断时代的发现
Antibiotics (Basel). 2020 Aug 17;9(8):524. doi: 10.3390/antibiotics9080524.
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List of new names and new combinations previously effectively, but not validly, published.先前已有效发表但未合法发表的新名称和新组合列表。
Int J Syst Evol Microbiol. 2020 Jul;70(7):4043-4049. doi: 10.1099/ijsem.0.004244.
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