Konjikusic Ana, Ohrndorf Sarah, Braun Tanja, Kluckow Vivien, Höhne-Zimmer Vera, Schmittat Gabriela, Heim Christine, Uebelhack Ralf, Minden Kirsten, Detert Jacqueline, Burmester Gerd-Rüdiger, Schaumburg Desiree
Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Charitéplatz, Germany.
Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Psychology, Berlin, Charitéplatz, Germany.
Front Med (Lausanne). 2025 Aug 5;12:1582075. doi: 10.3389/fmed.2025.1582075. eCollection 2025.
To compare the prevalence of childhood trauma, depression, and anxiety disorders between patients with early arthritis (EA) and a control group (CG). We further aimed to explore the influence of these variables on EA diagnosis.
This monocentric study included 60 prospectively recruited EA patients with at least one inflammatory joint with a symptom duration of 1-12 months. The CG consisted of 60 individuals with no clinical signs of arthritis. The participants underwent a semi-structured interview screening for psychiatric disorders and completed standardized questionnaires, including the Hospital Anxiety and Depression Scale (HADS-A, HADS-D), the Childhood Trauma Questionnaire (CTQ), and the Posttraumatic Diagnostic Scale (PDS). For statistical analysis, we used SPPS© χ test, T-test, Mann-Whitney U-test, and binominal regression analysis.
Compared to the CG, patients with EA had significantly higher rates of depression in the interview (41.7% vs. 16.7%; = 0.03) and PTSD (13.3% vs. 3.3%; = 0.048), and significantly higher HADS-D and CTQ childhood sexual abuse mean scores (HADS-D: 5.40 ± 4.80 vs. 3.60 ± 3.30; = 0.047; CTQ sexual abuse: 5.91 ± 2.68 vs. 5.15 ± 1.02; = 0.042). Binomial regression analysis revealed higher odds ratios for EA for CTQ emotional neglect ( = 0.048, OR = 1.12), CTQ sexual abuse ( = 0.040, OR = 1.4), HADS-D ( = 0.025, OR = 1.12), and lifetime depression ( = 0.040, OR = 4.00).
The high rates of depression and PTSD in EA emphasize a potential link between psychiatric disorders and arthritis. The presence of EA might be associated with present and lifetime depressive symptoms, childhood sexual abuse and emotional neglect.
比较早期关节炎（EA）患者与对照组（CG）儿童期创伤、抑郁症和焦虑症的患病率。我们还旨在探讨这些变量对EA诊断的影响。
这项单中心研究纳入了60例前瞻性招募的EA患者，这些患者至少有一个炎症关节，症状持续时间为1至12个月。CG由60名无关节炎临床体征的个体组成。参与者接受了精神障碍的半结构式访谈筛查，并完成了标准化问卷，包括医院焦虑抑郁量表（HADS-A、HADS-D）、儿童创伤问卷（CTQ）和创伤后诊断量表（PDS）。对于统计分析，我们使用了SPPS©卡方检验、t检验、曼-惠特尼U检验和二项回归分析。
与CG相比，EA患者在访谈中的抑郁症患病率（41.7%对16.7%；P = 0.03）和创伤后应激障碍（PTSD）患病率（13.3%对3.3%；P = 0.048）显著更高，HADS-D和CTQ儿童期性虐待平均得分也显著更高（HADS-D：5.40±4.80对3.60±3.30；P = 0.047；CTQ性虐待：5.91±2.68对5.15±1.02；P = 0.042）。二项回归分析显示，CTQ情感忽视（P = 0.048，OR = 1.12）、CTQ性虐待（P = 0.040，OR = 1.4）、HADS-D（P = 0.025，OR = 1.12）和终生抑郁症（P = 0.040，OR = 4.00）的EA比值比更高。
EA患者中抑郁症和PTSD的高患病率强调了精神障碍与关节炎之间的潜在联系。EA的存在可能与当前和终生抑郁症状、儿童期性虐待和情感忽视有关。
