Tiwari Neema, Tiwari Archita Kansal, Bansal Rani, Tomar Shivani
Department of Pathology, Subharti Medical College, Meerut, Uttar Pradesh, India.
Asian J Transfus Sci. 2025 Jan-Jun;19(1):173-176. doi: 10.4103/ajts.ajts_17_22. Epub 2022 Dec 12.
Autoimmune hemolytic anemias (AIHAs) are not very common, and autoimmunity is an important cause of hemolytic anemia, especially in female population. Some primary AIHAs are cold or warm agglutinin mediated anemia. Autoimmune reaction leads to macrophage activation as well as conversion of normal RBCs into spherocytes leading to their destruction and causing hemolysis leading to anemia. Rarely autoimmune phenomena can lead to agglutination however Cold agglutinin disease or Warm agglutinin disease have specific tests which are diagnostic for them. Here, we highlight a known case of Grave's disease who was admitted to the emergency and on sampling the peripheral blood repeated agglutination/clumping of RBCs occurred on glass surface but nothing happened in the plastic EDTA tube. This to the authors was extremely puzzling phenomena which occurred even on repeat sample for the case, Hence the authors warranted a need to discuss this.
自身免疫性溶血性贫血（AIHA）并不常见，自身免疫是溶血性贫血的重要原因，在女性人群中尤为如此。一些原发性AIHA是由冷或温凝集素介导的贫血。自身免疫反应导致巨噬细胞活化，以及正常红细胞转化为球形红细胞，导致其破坏并引起溶血，进而导致贫血。自身免疫现象很少会导致凝集，然而冷凝集素病或温凝集素病有特定的诊断测试。在此，我们重点介绍一例已知的格雷夫斯病病例，该患者被送往急诊室，采集外周血时，红细胞在玻璃表面反复发生凝集/聚集，但在塑料乙二胺四乙酸（EDTA）管中却没有出现这种情况。对作者来说，这是一个极其令人困惑的现象，即使对该病例进行重复采样时也会出现，因此作者认为有必要对此进行讨论。
