Musa Rozi Hanisa, Ahmad Nor Hafizah, Muniandi Gunaseelan, Mahmud Nor Nazahah, Ismail Ahmad Arif Che, Zahrin Mohammad Masrin Md, Kambali Mohd Muhaimin, Amin Nor Amiza Mat, Noor Sabariah Mohd, Sahid Salman Mohd, Sabri Shahnaz Irwani, Kadir Siti Nadiah Abdul, Soo Peng Yen, Kassim Zanariah, Aziz Mohd Fahmi, Ahmad Nafishah, Yahaya Wan Noor Falah Wan, Amin Noryati Abu
National Immunohematology Reference Laboratory, National Blood Centre, Jalan Tun Razak, Kuala Lumpur, Malaysia.
Department of Transfusion Medicine, Hospital Raja Perempuan Zainab II, Jalan Hospital, Kelantan, Malaysia.
Asian J Transfus Sci. 2025 Jan-Jun;19(1):29-35. doi: 10.4103/ajts.ajts_104_22. Epub 2023 May 11.
As is widely known, blood group antigens are found in varying proportions in individuals of different races and geographical places. The aim of this study is to determine and compare the distribution of red blood cell (RBC) phenotypes in blood donors between the major ethnic groups in Peninsular Malaysia, Sabah, and Sarawak based on the Malaysian population.
A total of 1213 voluntary blood donors were randomly recruited among those who donated in the National Blood Centre and 10 other different blood banks in state hospitals or their mobile blood donation sessions from January 2021 to December 2021. All donors were typed for blood group systems: ABO, Rh, Kidd, Duffy, MNS, and Kell by automated system using the Galileo Neo Analyser.
The comparison of the prevalence of the RBC phenotypes among the different ethnic groups as analyzed by Fisher's exact test, showed significant differences ( < 0.05) for Rh, Kidd, Duffy, MN, and Ss blood group antigen. The rare phenotypes: CCDEE (RZRZ) was found in three Malay, Jk (a-b-) in one Chinese, and two Murut, and SS in 8 donors.
The mapping of RBC phenotypes among major ethnic groups in blood donors in Peninsular, Sabah, and Sarawak, Malaysia, can aid in strengthening the database for the Rare Blood Donor Registry based on the Malaysian population. This study's finding can also be used to expedite the provision of antigen-negative blood for the transfusion of patients with unexpected red cells antibodies. This will improve the quality and effectiveness of transfusion services in Malaysia.
众所周知，不同种族和地理位置的个体中血型抗原的比例各不相同。本研究的目的是根据马来西亚人口，确定并比较马来西亚半岛、沙巴和砂拉越主要族群献血者中红细胞（RBC）表型的分布情况。
2021年1月至2021年12月期间，在国家血液中心以及州立医院的其他10家不同血库或其流动献血活动中随机招募了1213名自愿献血者。所有献血者均使用伽利略Neo分析仪通过自动化系统进行ABO、Rh、基德、达菲、MNS和凯尔血型系统的分型。
通过费舍尔精确检验分析不同族群中RBC表型的患病率比较，结果显示Rh、基德、达菲、MN和Ss血型抗原存在显著差异（<0.05）。发现罕见表型：CCDEE（RZRZ）在3名马来人中出现，Jk（a-b-）在1名中国人和2名穆鲁特人中出现，以及SS在8名献血者中出现。
绘制马来西亚半岛、沙巴和砂拉越献血者主要族群中的RBC表型图谱，有助于加强基于马来西亚人口的稀有献血者登记数据库。本研究结果还可用于加快为有意外红细胞抗体的患者输血提供抗原阴性血液。这将提高马来西亚输血服务的质量和效率。
