Sbarra David A, Trejo Sam, Harden K Paige, Oliver Jeffrey C, Klimentidis Yann C
Department of Psychology, University of Arizona.
Department of Sociology, Princeton University.
J Psychopathol Clin Sci. 2025 Oct;134(7):746-760. doi: 10.1037/abn0001051. Epub 2025 Aug 21.
The developmental pathways linking genetic risk for depression and depressive symptoms in adulthood remain poorly understood. Using data from the National Longitudinal Study of Adolescent Health ( = 5,690), we found that the association between genetic risk for depressive symptoms and increases in depressive symptoms from early adolescence to adulthood was partially mediated by four socioeconomic resource variables assessed in adulthood: educational attainment, total assets, debt, and access to health insurance. In a preregistered and confirmatory replication using data from the Wisconsin Longitudinal Study ( = 8,964), the genetic risk for depression symptoms change across late midlife was again partially mediated by the four socioeconomic resource variables. Using within-family, sibling-difference analyses, however, we found no evidence in support of direct genetic effects on the putative environmental mediators. The results highlight the need to explore between- and within-family model specifications for a more complete understanding of gene-environment pathways to psychiatric disease. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
将抑郁症的遗传风险与成年期抑郁症状联系起来的发育途径仍未得到充分理解。利用青少年健康全国纵向研究（N = 5690）的数据，我们发现，抑郁症状的遗传风险与从青春期早期到成年期抑郁症状增加之间的关联部分是由成年期评估的四个社会经济资源变量介导的：教育程度、总资产、债务和医疗保险覆盖情况。在一项使用威斯康星纵向研究（N = 8964）数据进行的预注册和验证性重复研究中，中年后期抑郁症状的遗传风险变化再次部分由这四个社会经济资源变量介导。然而，通过家庭内部、兄弟姐妹差异分析，我们没有发现支持对假定环境中介因素存在直接遗传效应的证据。结果强调，需要探索家庭间和家庭内模型规范，以便更全面地理解精神疾病的基因-环境途径。（PsycInfo数据库记录（c）2025美国心理学会，保留所有权利）
