Gooren L J
Arch Sex Behav. 1985 Dec;14(6):539-48. doi: 10.1007/BF01541754.
This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters of sexual functions. Replacement of testosterone substitution therapy of agonadal men by dihydrotestosterone was likewise not associated with any change of sexual functioning. Administration of dihydrotestosterone to eugonadal men led to a transient increase of nocturnal sexual dreams and erections and irritability, waning after 3-4 weeks of dihydrotestosterone administration. It is concluded that aromatization of testosterone is not required and that dihydrotestosterone maintains sexual functions in the adult male with an established sex life.
本研究旨在探讨睾酮是否需要转化为雌二醇才能充分发挥其对男性性功能的作用。给予雌激素受体拮抗剂他莫昔芬和芳香化酶抑制剂睾内酯对性功能参数没有影响。用双氢睾酮替代性腺功能减退男性的睾酮替代疗法同样未引起性功能的任何变化。对性腺功能正常的男性给予双氢睾酮会导致夜间性梦和勃起以及易怒情绪短暂增加，在给予双氢睾酮3 - 4周后逐渐减弱。结论是睾酮的芳香化并非必需，且双氢睾酮可维持成年男性已建立性生活的性功能。
