脑内芳香化作用：经典作用与新视角
Brain aromatization: classic roles and new perspectives.
作者信息
Roselli Charles E, Liu Mingyue, Hurn Patricia D
机构信息
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201-3098, USA.
出版信息
Semin Reprod Med. 2009 May;27(3):207-17. doi: 10.1055/s-0029-1216274. Epub 2009 Apr 28.
Abstract
Aromatization of testosterone to estradiol by neural tissue has classically been associated with the regulation of sexual differentiation, gonadotropin secretion, and copulatory behavior. However, new data indicate that the capacity for aromatization is not restricted to the endocrine brain and demonstrate roles for locally formed estrogens in neurogenesis and in responses of brain tissue to injury. This article summaries our current understanding of the distribution and regulation of aromatase in the brain and describes the classic and novel roles it plays. A better understanding of brain aromatization could shed new light on its physiologic and pathologic functions and someday lead to new, centrally acting drug therapies.
摘要
神经组织将睾酮芳香化为雌二醇的过程，传统上一直与性别分化、促性腺激素分泌及交配行为的调节相关。然而，新数据表明，芳香化能力并不局限于内分泌脑区，且局部生成的雌激素在神经发生及脑组织对损伤的反应中发挥作用。本文总结了我们目前对脑中芳香化酶分布与调节的理解，并描述了其发挥的经典及新作用。对脑芳香化作用的更好理解，可能会为其生理和病理功能带来新的认识，并有朝一日带来新的中枢作用药物疗法。
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