Asin K E, Wirtshafter D, Fibiger H C
Behav Neural Biol. 1985 Nov;44(3):415-24. doi: 10.1016/s0163-1047(85)90784-8.
We have previously reported that electrolytic lesions of the nucleus medianus raphe (MR) produce a deficit in the acquisition of an 8-arm radial maze task (Wirtshafter and Asin 1983). In an attempt to determine whether or not this deficit is secondary to serotonin depletion resulting from the lesion, we investigated and compared the effects of electrolytic and 5,7-dihydroxytryptamine (5,7-DHT) lesions of the MR on the acquisition of the radial maze task. Although forebrain serotonin levels after 5,7-DHT injections were reduced as much as those following electrolytic lesions, only rats with an electrolytic MR lesion were impaired on the acquisition of both a free-running maze task and on a related task, where animals were replaced into the same arm between arm choices. In contrast, 5,7-DHT-treated rats were unimpaired on both tasks compared to an ascorbate-injected control group. These findings provide further evidence that most of the profound behavioral deficits shown by rats with electrolytic MR damage are not due to serotonin depletion and are consistent with the results of other studies indicating strong similarities between the behavioral effects of limbic and MR lesions.
我们之前曾报道，中缝正中核（MR）的电解损伤会导致在八臂放射状迷宫任务的习得中出现缺陷（Wirtshafter和Asin，1983年）。为了确定这种缺陷是否继发于损伤导致的血清素耗竭，我们研究并比较了MR的电解损伤和5,7-二羟基色胺（5,7-DHT）损伤对放射状迷宫任务习得的影响。尽管注射5,7-DHT后前脑血清素水平的降低程度与电解损伤后的降低程度相同，但只有电解性MR损伤的大鼠在自由运行迷宫任务以及一项相关任务（即在每次选择臂之间将动物放回同一臂的任务）的习得中受损。相比之下，与注射抗坏血酸的对照组相比，5,7-DHT处理的大鼠在这两项任务中均未受损。这些发现进一步证明，电解性MR损伤的大鼠所表现出的大多数严重行为缺陷并非由于血清素耗竭，并且与其他研究结果一致，这些研究表明边缘系统和MR损伤的行为效应之间存在很强的相似性。
