Rodríguez-Castañeda Manuela, Campos-Ríos Ana, Lamas Jose Antonio, Covelo Ana
Department of Functional Biology and Health Sciences, University of Vigo, Vigo, Spain.
CINBIO, University of Vigo, Vigo, Spain.
Front Cell Neurosci. 2025 Aug 6;19:1650326. doi: 10.3389/fncel.2025.1650326. eCollection 2025.
Despite long being considered to be passive and supportive cells, in the last decades astrocytes have arisen as key regulators of neuronal excitability, synaptic transmission and plasticity. Since the discovery of the tripartite synapse, accumulating evidence suggests that astrocytes are involved in the pathogenesis of neurodegenerative diseases, including α-synucleinopathies. Here we will discuss recent evidence showing that astrocytes express endogenous α-synuclein and the implications of this protein in astrocyte cellular processes. Furthermore, we review how the expression of pathological forms of this protein in astrocytes leads to aberrant cytosolic Ca activity in these cells and to alterations in gliotransmission and pathology progression.
尽管长期以来被认为是被动的支持性细胞，但在过去几十年中，星形胶质细胞已成为神经元兴奋性、突触传递和可塑性的关键调节因子。自从三联突触被发现以来，越来越多的证据表明星形胶质细胞参与神经退行性疾病的发病机制，包括α-突触核蛋白病。在这里，我们将讨论最近的证据，这些证据表明星形胶质细胞表达内源性α-突触核蛋白以及该蛋白在星形胶质细胞的细胞过程中的意义。此外，我们还将综述该蛋白的病理形式在星形胶质细胞中的表达如何导致这些细胞异常的胞质钙活性以及胶质递质传递和病理进展的改变。
