Li Dong, Xu Jia-Neng, Chen Han-Kai, Ren Qiang, Li Yu-Min
Department of Urology, Jiashan First People's Hospital, Jiaxing, Zhejiang, China.
Front Oncol. 2025 Aug 6;15:1625901. doi: 10.3389/fonc.2025.1625901. eCollection 2025.
This systematic review and meta-analysis compared the efficacy of Holmium Laser and Plasma Techniques in treating non-muscle invasive bladder cancer (NMIBC), focusing on surgical duration, safety, and tumor recurrence.
Adhering to PRISMA guidelines, we included randomized controlled trials that directly compared Holmium Laser and Plasma Techniques in NMIBC treatment. The Cochrane Collaboration's tool assessed study quality, and statistical analyses were conducted using fixed-effect or random-effects models based on heterogeneity. Sensitivity analyses and publication bias assessments were also performed.
Our search yielded 1158 potentially relevant articles, with 8 studies meeting our inclusion criteria. The analysis showed no significant difference in surgical duration between the two techniques. However, the Holmium Laser was associated with a significantly lower incidence of intraoperative bladder perforation (RR=0.10, P<0.001) and a reduced short-term tumor recurrence rate (RR=0.65, P<0.01). Sensitivity analysis confirmed the robustness of these findings, and no significant publication bias was detected.
Holmium Laser provides safer outcomes and better efficacy in reducing postoperative tumor recurrence compared to Plasma Techniques in NMIBC management.
本系统评价和荟萃分析比较了钬激光和等离子技术治疗非肌层浸润性膀胱癌（NMIBC）的疗效，重点关注手术时间、安全性和肿瘤复发情况。
遵循PRISMA指南，我们纳入了直接比较钬激光和等离子技术治疗NMIBC的随机对照试验。采用Cochrane协作网工具评估研究质量，并根据异质性使用固定效应或随机效应模型进行统计分析。还进行了敏感性分析和发表偏倚评估。
我们的检索共获得1158篇可能相关的文章，其中8项研究符合纳入标准。分析表明，两种技术在手术时间上无显著差异。然而，钬激光与术中膀胱穿孔发生率显著降低（RR = 0.10，P < 0.001）和短期肿瘤复发率降低（RR = 0.65，P < 0.01）相关。敏感性分析证实了这些发现的稳健性，未检测到显著的发表偏倚。
在NMIBC治疗中，与等离子技术相比，钬激光在减少术后肿瘤复发方面具有更安全的结果和更好的疗效。
