Tripepi Marta, da Costa Ana G, Albergaria Diogo, Costa Andreia, Catarino Ana, Duarte Ana Luisa, Bartosch Carla, Schuler Veronica, Oliveira Joana, Lima Jorge, Casanova João
Department of Women and Children's Health, Clinic of Gynecology and Obstetrics, University of Padua, Padua, Italy.
Gynecologic Oncology Unit, Obstetrics and Gynecology Service, Department of Surgery, Hospital da Luz Lisboa, Lisbon, Portugal.
Front Oncol. 2025 Aug 6;15:1648580. doi: 10.3389/fonc.2025.1648580. eCollection 2025.
Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare, highly aggressive malignancy that predominantly affects young women. We report a 32-year-old pregnant woman diagnosed with SCCOHT during the first trimester of pregnancy. At 24 weeks, imaging revealed extensive peritoneal carcinomatosis. Following multidisciplinary evaluation, neoadjuvant chemotherapy was initiated, but the disease progressed. At 34 weeks, the patient underwent cesarean delivery followed by cytoreductive surgery. Despite achieving an initial complete resection, the disease recurred rapidly. The patient died shortly after completing adjuvant chemotherapy and initiating immunotherapy. This case highlights the diagnostic and therapeutic challenges of managing SCCOHT during pregnancy and the complex balance of maternal and fetal outcomes. Early diagnosis, coordinated multidisciplinary care, and timely intervention are critical, although the prognosis remains poor despite aggressive multimodal treatment.
卵巢小细胞癌高钙血症型（SCCOHT）是一种罕见的、侵袭性很强的恶性肿瘤，主要影响年轻女性。我们报告一例32岁孕妇，在妊娠早期被诊断为SCCOHT。孕24周时，影像学检查显示广泛的腹膜癌转移。经过多学科评估后，开始进行新辅助化疗，但疾病仍进展。孕34周时，患者接受剖宫产，随后进行减瘤手术。尽管最初实现了完全切除，但疾病很快复发。患者在完成辅助化疗并开始免疫治疗后不久死亡。该病例突出了妊娠期间管理SCCOHT的诊断和治疗挑战，以及母婴结局之间的复杂平衡。尽管进行了积极的多模式治疗，预后仍然很差，但早期诊断、协调的多学科护理和及时干预至关重要。
