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乳房植入物引发的自身免疫/炎症综合征(ASIA):一例报告

Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in Breast Implants: A Case Report.

作者信息

Quiroz Diaz Humberto, Garcia Hernandez Alitzel, Castrejon Castro Ivonne

机构信息

General Surgery, Hospital General Regional No. 1 Instituto Mexicano del Seguro Social (IMSS), Santiago de Querétaro, MEX.

Plastic Surgery, Hospital de Especialidades Centro Medico Nacional SXXI, Mexico City, MEX.

出版信息

Cureus. 2025 Jul 21;17(7):e88418. doi: 10.7759/cureus.88418. eCollection 2025 Jul.

DOI:10.7759/cureus.88418
PMID:40842800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12366196/
Abstract

Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) encompasses all conditions capable of triggering systemic inflammatory processes due to the use of adjuvant materials, including the use of breast implants in plastic surgery procedures. These conditions typically cause symptoms such as pain, redness, erythema, or capsular contracture and ultimately lead to the removal of these materials, resulting in subsequent clinical improvement. We report the case of a 32-year-old woman with a history of autoimmune disease (Evans syndrome) who underwent breast implant placement and subsequently developed clinical features consistent with ASIA, accompanied by thrombocytopenia. Both clinical symptoms and laboratory parameters improved following explantation of the implants.

摘要

佐剂诱导的自身免疫/炎症综合征(ASIA)包括所有因使用佐剂材料而能够引发全身炎症过程的病症,包括在整形手术中使用乳房植入物的情况。这些病症通常会引起疼痛、发红、红斑或包膜挛缩等症状,并最终导致移除这些材料,随后临床症状改善。我们报告了一例32岁有自身免疫性疾病(伊文斯综合征)病史的女性病例,该患者接受了乳房植入手术,随后出现了与ASIA相符的临床特征,并伴有血小板减少症。植入物取出后,临床症状和实验室指标均有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccc0/12366196/ef59357fb4b5/cureus-0017-00000088418-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccc0/12366196/ef59357fb4b5/cureus-0017-00000088418-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccc0/12366196/ef59357fb4b5/cureus-0017-00000088418-i01.jpg

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本文引用的文献

1
Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) after Silicone Breast Implants.硅胶乳房植入术后佐剂诱导的自身免疫/炎症综合征(ASIA)
Eur J Case Rep Intern Med. 2025 Jan 7;12(2):005048. doi: 10.12890/2025_005048. eCollection 2025.
2
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023.2023 年的佐剂诱发的自身免疫/炎症综合征(ASIA)。
Autoimmun Rev. 2023 May;22(5):103287. doi: 10.1016/j.autrev.2023.103287. Epub 2023 Feb 3.
3
Breast implant illness: scientific evidence of its existence.乳房植入病:其存在的科学证据。
Expert Rev Clin Immunol. 2022 Jan;18(1):15-29. doi: 10.1080/1744666X.2022.2010546. Epub 2022 Jan 5.
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ASIA Syndrome Following Breast Implant Placement.乳房植入术后的亚洲综合征
Isr Med Assoc J. 2018 Nov;20(11):714-716.
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Vitamin D deficiency as a risk factor for the development of autoantibodies in patients with ASIA and silicone breast implants: a cohort study and review of the literature.维生素D缺乏作为亚洲患者和硅胶乳房植入物自身抗体产生的危险因素:一项队列研究及文献综述
Clin Rheumatol. 2017 May;36(5):981-993. doi: 10.1007/s10067-017-3589-6. Epub 2017 Mar 17.
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Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome) - An update.佐剂诱导的自身免疫性/炎症综合征(肖费尔德综合征)——最新进展
Lupus. 2017 Jun;26(7):675-681. doi: 10.1177/0961203316686406. Epub 2017 Jan 6.
7
Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.硅胶植入后200例亚洲综合征病例:30年的比较研究及当前文献综述
Immunol Res. 2017 Feb;65(1):120-128. doi: 10.1007/s12026-016-8821-y.
8
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk?硅胶植入后佐剂诱导的自身免疫/炎症综合征(ASIA)的演变。哪些人有风险?
Clin Rheumatol. 2015 Oct;34(10):1661-6. doi: 10.1007/s10067-015-2931-0. Epub 2015 Apr 16.