Yousfi Jaouad, Oumlil Soukaina, Essaadouni Lamiaa
Department of Internal Medicine, University Hospital of Mohammed VI, Marrakesh, Morocco.
Eur J Case Rep Intern Med. 2025 Jan 7;12(2):005048. doi: 10.12890/2025_005048. eCollection 2025.
Autoimmune/inflammatory syndrome is a complex condition characterized by various autoimmune and inflammatory symptoms following the exposure to an adjuvant such as silicone. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is challenging to diagnose because it can mimic other autoimmune diseases and requires specific criteria for identification. We report a case of a 35-year-old woman who developed inflammatory joint pain, fatigue and myalgia after receiving silicone breast implants. Symptoms improved significantly after administration of steroids. Based on the fulfilment of the ASIA diagnostic criteria, the diagnosis was made. This case emphasizes the importance of understanding this condition in patients with unexplained systemic symptoms after exposure to adjuvants.
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) should be considered in patients with unexplained systemic symptoms following exposure to adjuvants.Steroids can offer significant symptom relief; however, implant removal may be necessary if symptoms persist or recur.Awareness of ASIA can help in early diagnosis, and in improving patient outcomes.
自身免疫性/炎症综合征是一种复杂病症，其特征为接触如硅酮等佐剂后出现各种自身免疫和炎症症状。佐剂诱导的自身免疫性/炎症综合征（ASIA）诊断具有挑战性，因为它可能模仿其他自身免疫性疾病，且需要特定的识别标准。我们报告一例35岁女性病例，该患者在接受硅酮乳房植入物后出现炎性关节疼痛、疲劳和肌痛。使用类固醇后症状显著改善。基于符合ASIA诊断标准，做出了诊断。该病例强调了在接触佐剂后出现不明原因全身症状的患者中了解这种病症的重要性。
接触佐剂后出现不明原因全身症状的患者应考虑佐剂诱导的自身免疫性/炎症综合征（ASIA）。类固醇可显著缓解症状；然而，如果症状持续或复发，可能需要取出植入物。认识ASIA有助于早期诊断并改善患者预后。
