Yu Ming, Yi Ying, Yang Honglin, Zhang Yi
Institute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi, China.
Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, China.
Front Microbiol. 2025 Aug 6;16:1632425. doi: 10.3389/fmicb.2025.1632425. eCollection 2025.
Autophagy is the process by which cells degrade and recycle damaged organelles and macromolecules by forming autophagosomes. This process is closely related to the maintenance of cellular homeostasis, ontogeny, and the occurrence and development of various diseases. Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins but play crucial roles in regulating gene expression. Numerous studies have demonstrated that ncRNAs are involved in regulating autophagy, and accumulating scientific evidence suggests that ncRNAs play an essential role in virus-induced cellular autophagy. ncRNAs affect autophagy by participating in the autophagy regulatory network, mediating the transcriptional and post-transcriptional regulation of autophagy-related genes. This review aims to explore the role of ncRNAs in autophagy induced by viral infection and analyze the relevant molecular regulatory mechanisms underlying autophagy. By examining the content above, we speculate that targeted regulation of ncRNAs can affect autophagy induced upon viral infection, thereby achieving antiviral effects and host cell protection.
自噬是细胞通过形成自噬体来降解和回收受损细胞器及大分子的过程。该过程与细胞稳态的维持、个体发育以及各种疾病的发生发展密切相关。非编码RNA（ncRNA）是一类不编码蛋白质但在调节基因表达中起关键作用的RNA分子。大量研究表明，ncRNA参与调节自噬，越来越多的科学证据表明，ncRNA在病毒诱导的细胞自噬中起重要作用。ncRNA通过参与自噬调控网络、介导自噬相关基因的转录和转录后调控来影响自噬。本综述旨在探讨ncRNA在病毒感染诱导的自噬中的作用，并分析自噬相关的分子调控机制。通过研究上述内容，我们推测对ncRNA的靶向调控可影响病毒感染时诱导的自噬，从而实现抗病毒作用并保护宿主细胞。
