School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
CNS Neurosci Ther. 2024 May;30(5):e14763. doi: 10.1111/cns.14763.
Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy-a crucial cellular process for maintaining protein and organelle integrity.
This review focuses on the role of non-coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology. Special attention was given to the examination of ncRNAs' regulatory impacts in various PD models and patient samples.
Findings reveal that ncRNAs are pivotal in regulating key processes associated with PD progression, including autophagy, α-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. Dysregulation of specific ncRNAs appears to be closely linked to these pathogenic processes.
ncRNAs hold significant therapeutic potential for addressing autophagy-related mechanisms in PD. The review highlights innovative therapeutic strategies targeting autophagy-related ncRNAs and discusses the challenges and prospective directions for developing ncRNA-based therapies in clinical practice. The insights from this study underline the importance of ncRNAs in the molecular landscape of PD and their potential in novel treatment approaches.
帕金森病（PD）是一种退行性神经疾病，其特征是黑质致密部多巴胺能神经元逐渐丧失。PD 的确切病因仍不清楚，但新出现的证据表明自噬失调在其中起着重要作用——自噬是维持蛋白质和细胞器完整性的关键细胞过程。
本综述重点探讨了非编码 RNA（ncRNA）在调节 PD 中自噬的作用。我们对最近的研究进行了全面综述，以探讨 ncRNA 如何影响自噬并促进 PD 病理生理学。特别关注了 ncRNA 在各种 PD 模型和患者样本中的调节作用的研究。
研究结果表明，ncRNA 在调节与 PD 进展相关的关键过程中起着关键作用，包括自噬、α-突触核蛋白聚集、线粒体功能障碍和神经炎症。特定 ncRNA 的失调似乎与这些致病过程密切相关。
ncRNA 在解决 PD 中与自噬相关的机制方面具有重要的治疗潜力。该综述强调了针对自噬相关 ncRNA 的创新治疗策略，并讨论了在临床实践中开发基于 ncRNA 的治疗方法的挑战和未来方向。这项研究的结果强调了 ncRNA 在 PD 分子图谱中的重要性及其在新型治疗方法中的潜力。
