Kang Joongyu, Choi Jin Ho, Lee Sang Hyub, Kim Junyeol, Lee Tae Seung, Chang Sung Hoon, Song Yong Soo, Cho In Rae, Paik Woo Hyun, Ryu Ji Kon
Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Republic of Korea Army, Republic of Korea.
J Ginseng Res. 2025 Sep;49(5):502-508. doi: 10.1016/j.jgr.2025.04.003. Epub 2025 Apr 12.
Managing symptoms of chronic pancreatitis (CP) remains a significant challenge. Korean Red ginseng (KRG), a well-known herbal supplement, has shown potential benefits in various health conditions, prompting its investigation in CP patients.
We conducted a single-arm, prospective clinical trial to evaluate the effect of KRG on quality of life in CP patients exhibiting mild symptoms, as defined by a Clinical Global Impression (CGI) score of 0 or 1. 40 patients were enrolled and assessed at baseline, as well as at 30, 90, and 180 days. The primary outcome was an improvement in CGI scores, with secondary outcomes including changes in Pancreatic Exocrine Insufficiency Questionnaire (PEI-Q) scores.
A total of 40 patients were enrolled in this study, and 39 participants were analyzed. Results showed significant improvements in CGI scores at all examined intervals (days 0-30, 0-90, 0-180; p < 0.05). The PEI-Q score also significantly improved from day 0 to day 180 (p < 0.05). Two adverse events (AEs) probably related to KRG were reported, and all AEs were improved with conservative managements.
KRG supplementation significantly improves quality of life in CP patients with mild symptoms. These findings suggest that KRG may be a beneficial adjunct therapy in this patient population. Further research is needed to explore KRG's pharmacological mechanisms, its use in combination with other treatments, and its effects in patients with more severe symptoms. (CRIS number: KCT0009681).
慢性胰腺炎（CP）症状的管理仍然是一项重大挑战。高丽参（KRG）是一种著名的草药补充剂，已在各种健康状况中显示出潜在益处，促使对CP患者进行研究。
我们进行了一项单臂前瞻性临床试验，以评估KRG对临床总体印象（CGI）评分为0或1所定义的轻度症状的CP患者生活质量的影响。招募了40名患者，并在基线以及第30、90和180天进行评估。主要结局是CGI评分的改善，次要结局包括胰腺外分泌功能不全问卷（PEI-Q）评分的变化。
本研究共招募了40名患者，对39名参与者进行了分析。结果显示，在所有检查间隔（第0 - 30天、0 - 90天、0 - 180天）CGI评分均有显著改善（p < 0.05）。PEI-Q评分从第0天到第180天也有显著改善（p < 0.05）。报告了两例可能与KRG相关的不良事件（AE），所有AE通过保守治疗均得到改善。
补充KRG可显著改善轻度症状CP患者的生活质量。这些发现表明，KRG可能是该患者群体有益的辅助治疗方法。需要进一步研究以探索KRG的药理机制、其与其他治疗联合使用的情况以及其在症状更严重患者中的效果。（CRIS编号：KCT0009681）
