Park Soo Kyung, Hyun Sun Hee, In Gyo, Park Chae-Kyu, Kwak Yi-Seong, Jang Young-Jin, Kim Bumseok, Kim Jong-Hoon, Han Chang-Kyun
Laboratory of Efficacy Research, Korea Ginseng Corporation, 30, Gajeong-ro, Shinseong-dong, Yuseong-gu, Daejeon, Republic of Korea.
College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University, Iksan-city, Republic of Korea.
J Ginseng Res. 2021 Jan;45(1):41-47. doi: 10.1016/j.jgr.2020.09.006. Epub 2020 Oct 10.
A wide range of studies have steadily pointed out the relation of oxidative stress to the primary and secondary causes of human disease and aging. As such, there have been multiple misconceptions about oxidative stress. Most of reactive oxygen species (ROS) generated from chronic diseases cause oxidative damage to cell membrane lipids and proteins. ROS production is increased by abnormal stimulation inside and outside in the body, and even though ROS are generated in cells in response to abnormal metabolic processes such as disease, it does not mean that they directly contribute to the pathogenesis of a disease. Therefore, the focus of treatment should not be on ROS production itself but on the prevention and treatment of diseases linked to ROS production, including types 1 and 2 diabetes, cancer, heart disease, schizophrenia, Parkinson's disease, and Alzheimer's disease. In this regard, Korean Red Ginseng (KRG) has been traditionally utilized to help prevent and treat diseases such as diabetes, cancer, inflammation, nervous system diseases, cardiovascular disease, and hyperlipidemia. Therefore, this review was intended to summarize animal and human clinical studies on the antioxidant activities of KRG and its components, ginsenosides.
大量研究不断指出氧化应激与人类疾病及衰老的主要和次要原因之间的关系。正因如此，人们对氧化应激存在多种误解。大多数由慢性疾病产生的活性氧（ROS）会对细胞膜脂质和蛋白质造成氧化损伤。体内外的异常刺激会增加ROS的产生，并且即使ROS是细胞响应诸如疾病等异常代谢过程而产生的，但这并不意味着它们直接导致疾病的发病机制。因此，治疗的重点不应是ROS的产生本身，而应是预防和治疗与ROS产生相关的疾病，包括1型和2型糖尿病、癌症、心脏病、精神分裂症、帕金森病和阿尔茨海默病。在这方面，韩国红参（KRG）传统上一直被用于帮助预防和治疗糖尿病、癌症、炎症、神经系统疾病、心血管疾病和高脂血症等疾病。因此，本综述旨在总结关于KRG及其成分人参皂苷抗氧化活性的动物和人体临床研究。
