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Substance use comorbidity in bipolar disorder: A qualitative review of treatment strategies and outcomes.双相障碍中的物质使用共病：治疗策略和结果的定性综述。
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Adjunctive psychosocial intervention following Hospital discharge for Patients with bipolar disorder and comorbid substance use: A pilot randomized controlled trial.双相情感障碍合并物质使用患者出院后的辅助心理社会干预：一项随机对照试验的初步研究
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A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence.喹硫平作为双相 I 型患者共病酒精依赖的锂盐或丙戊酸钠辅助治疗的双盲、安慰剂对照研究。
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双相情感障碍与物质使用障碍共病的心理社会和心理药物干预：综述

Psychosocial and Psychopharmacological Interventions for Comorbid Bipolar Disorder and Substance Use Disorders: A Review.

作者信息

O'Hearn Broghan, Akpolat Nur, Kobaissi Hadi, Kamali Masoud, Nierenberg Andrew A, Sylvia Louisa G, Gold Alexandra K

机构信息

Department of Psychiatry, Massachusetts General Hospital, (BO, NA, HK, MK, AAN, LGS, AKG), and Harvard Medical School (AAN, LGS, AKG), Boston, Massachusetts.

出版信息

Psychiatr Ann. 2024 Sep;54(9):e258-e262. doi: 10.3928/00485713-20240918-01. Epub 2024 Oct 9.

DOI:10.3928/00485713-20240918-01
PMID:40843035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12366803/
Abstract

The co-occurrence of bipolar disorder and substance use disorders presents significant clinical challenges, complicating diagnosis, treatment, and prognosis. This review explores both psychosocial and psychopharmacological interventions evaluated in randomized, controlled trials to address this comorbidity. Findings indicate that while several interventions show promise, no single treatment is consistently effective across both mood and substance use domains as compared to placebo. These findings highlight the necessity of personalized, multimodal treatment plans tailored to the specific needs of individuals with comorbid bipolar disorder and substance use disorders.

摘要

双相情感障碍与物质使用障碍的共病带来了重大的临床挑战，使诊断、治疗和预后变得复杂。本综述探讨了在随机对照试验中评估的心理社会和心理药物干预措施，以解决这种共病问题。研究结果表明，虽然几种干预措施显示出前景，但与安慰剂相比，没有一种单一治疗方法在情绪和物质使用领域都始终有效。这些发现凸显了针对双相情感障碍与物质使用障碍共病个体的特定需求制定个性化多模式治疗计划的必要性。