Zhao Zhijie, Wei Xiaoyue, Wang Aimei, Wang Wanting, Meng Xiaofei, Liu Wentao, Chang Yanlin, Zhao Yakun, Li Guangkang, Chen Jianling, Li Yongli, You Yuanhai, Zhao Ling, Zhang Jianzhong, Yan Xianying, Cui Zhigang, Xu Guofeng, Zhou Haijian, Yan Xiaomei, Zhang Qingjie
Puyang Key Laboratory for Infectious Disease Prevention and Control, Puyang Center for Disease Control and Prevention, Puyang City, Henan Province, China.
National Key Laboratory for Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC Wkly. 2025 Aug 15;7(33):1093-1098. doi: 10.46234/ccdcw2025.184.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: () represents a clinically significant pathogen and serves as a common causative agent of foodborne intoxication. The strain ST59 constitutes the predominant clone associated with both community-associated methicillin-resistant (CA-MRSA) and hospital-associated MRSA (HA-MRSA) infections. However, staphylococcal food poisoning (SFP) outbreaks attributed to ST59 MRSA have been documented in only a limited number of Chinese cities through retrospective investigations.
WHAT IS ADDED BY THIS REPORT?: This report documents the first recorded outbreak of staphylococcal food poisoning (SFP) in Henan Province, which was attributed to the ST59- t441-SCC IVa CA-MRSA strain producing enterotoxins A and B. The confirmed source of the outbreak was contamination of donkey and goose meat with enterotoxins A and B. Additionally, comprehensive genomic analysis identified multiple virulence genes and antibiotic resistance genes within the outbreak-related strains.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: The identification of foodborne clones of ST59 CA-MRSA in this outbreak underscores the prevalence and transmission risks associated with this hypervirulent lineage. These findings highlight the critical need to strengthen surveillance measures for CA-MRSA among food industry workers and implement enhanced food safety protocols.
（）是一种具有临床意义的病原体，是食源性中毒的常见病原体。ST59菌株是与社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）和医院获得性耐甲氧西林金黄色葡萄球菌（HA-MRSA）感染相关的主要克隆。然而，通过回顾性调查，仅在中国少数城市记录了由ST59耐甲氧西林金黄色葡萄球菌引起的葡萄球菌食物中毒（SFP）暴发。
本报告记录了河南省首次有记录的葡萄球菌食物中毒（SFP）暴发，该暴发由产A和B型肠毒素的ST59-t441-SCC IVa CA-MRSA菌株引起。此次暴发的确认源头是驴肉和鹅肉被A和B型肠毒素污染。此外，全面的基因组分析在与此次暴发相关的菌株中鉴定出多个毒力基因和抗生素耐药基因。
此次暴发中鉴定出食源性ST59 CA-MRSA克隆，凸显了这种高毒力谱系的流行情况和传播风险。这些发现强调了加强对食品行业工人中CA-MRSA监测措施以及实施强化食品安全规程的迫切需求。
