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采用颊黏膜移植和阴道壁移植治疗女性尿道狭窄的背侧镶嵌式尿道成形术的疗效分析

Analysis of outcome of dorsal onlay urethroplasty using buccal mucosal graft and vaginal wall graft for female urethral stricture.

作者信息

Babelay Gaurav, Ahmad Ahsan, Ranjan Nikhil, Dheeraj Kumar

机构信息

Department of Urology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

出版信息

Urol Ann. 2025 Jul-Sep;17(3):156-160. doi: 10.4103/ua.ua_121_24. Epub 2025 Jul 18.

DOI:10.4103/ua.ua_121_24
PMID:40843397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12366848/
Abstract

BACKGROUND

It was estimated that 3%-8% of women presented with bladder obstruction, and 4%-13% of these women had female urethral stricture (FUS), which is an uncommon disorder.

AIMS

The study has been conducted to analyze the outcome of Dorsal onlay urethroplasty using buccal mucosal graft (BMG) and vaginal wall graft (VWG) for FUS.

SETTINGS AND DESIGN

It was a retrospective, single-centric cohort study. The study has been conducted for 2 years and 2 months, i.e., from July 2021 to September 2023.

SUBJECTS AND METHODS

The study included 20 female patients with urethral stricture who had urethroplasty. The participants were further classified into two groups respectively. One of the groups included 10 participants with cases of BMG urethroplasty and another 10 were cases of VWG urethroplasty.

STATISTICAL ANALYSIS

The Statistical Package for the Social Sciences (SPSS) version 24 program was used to analyze the data. Both continuous and categorical variables were present in the data. Descriptive Statistics were expressed as mean ± standard deviation or (%) or .

RESULTS

The BMG group had a substantially lower postvoid residual (PVR) of 10 ± 4.2 mL than the VWG group, which had a PVR of 15 ± 6.4 mL with a = 0.04. The operating time was 110 ± 10.8 in the BMG urethroplasty group and 90 ± 8.2 in the VWG group with a < 0.001. VWG urethroplasty group. No statistically significant differences were observed in terms of AUA symptom score and Q.

CONCLUSION

The study concluded that FUS reconstruction can offer a good, long-lasting response. Moreover, between both the preferred techniques of BMG and VWG urethroplasty, which is safe and effective, patients with postmenopausal atrophy or vaginal pathology may benefit more from BMG.

摘要

背景

据估计,3% - 8%的女性存在膀胱梗阻,其中4% - 13%的女性患有女性尿道狭窄(FUS),这是一种罕见的疾病。

目的

本研究旨在分析使用颊黏膜移植物(BMG)和阴道壁移植物(VWG)进行背侧覆盖尿道成形术治疗FUS的效果。

设置与设计

这是一项回顾性、单中心队列研究。研究持续了2年2个月,即从2021年7月至2023年9月。

对象与方法

该研究纳入了20例接受尿道成形术的女性尿道狭窄患者。参与者被进一步分为两组。其中一组包括10例接受BMG尿道成形术的患者,另一组10例为VWG尿道成形术患者。

统计分析

使用社会科学统计软件包(SPSS)24版程序分析数据。数据中既有连续变量也有分类变量。描述性统计以均值±标准差或(%)表示。

结果

BMG组的排尿后残余尿量(PVR)显著低于VWG组,分别为10±4.2 mL和15±6.4 mL,P = 0.04。BMG尿道成形术组的手术时间为110±10.8分钟,VWG组为90±8.2分钟,P < 0.001。在AUA症状评分和Q方面,未观察到统计学上的显著差异。

结论

该研究得出结论,FUS重建可提供良好的长期效果。此外,在BMG和VWG尿道成形术这两种首选技术中,二者均安全有效,绝经后萎缩或阴道病变的患者可能从BMG中获益更多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/12366848/7fa855cccfb5/UA-17-156-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/12366848/e73fd6ab6683/UA-17-156-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/12366848/7fa855cccfb5/UA-17-156-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/12366848/e73fd6ab6683/UA-17-156-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9532/12366848/7fa855cccfb5/UA-17-156-g002.jpg

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本文引用的文献

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Asian J Urol. 2024 Oct;11(4):611-617. doi: 10.1016/j.ajur.2024.01.002. Epub 2024 Jan 17.
2
Dorsal onlay urethroplasty using buccal mucosal graft and vaginal wall graft for female urethral stricture - Outcome of two-institution study.使用颊黏膜移植物和阴道壁移植物的背侧镶嵌式尿道成形术治疗女性尿道狭窄——一项双机构研究的结果
Indian J Urol. 2022 Apr-Jun;38(2):140-145. doi: 10.4103/iju.iju_329_21. Epub 2022 Apr 1.
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Ventral inlay labia minora graft urethroplasty for the management of female urethral strictures.
经阴道小阴唇皮瓣尿道成形术治疗女性尿道狭窄。
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Dorsal onlay vaginal graft urethroplasty for female urethral stricture.背侧嵌贴式阴道移植物尿道成形术治疗女性尿道狭窄
Indian J Urol. 2013 Apr;29(2):124-8. doi: 10.4103/0970-1591.114034.
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A systematic review of surgical techniques used in the treatment of female urethral stricture.外科技术治疗女性尿道狭窄的系统评价。
Eur Urol. 2013 Dec;64(6):965-73. doi: 10.1016/j.eururo.2013.07.038. Epub 2013 Aug 3.
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Dorsal vaginal graft urethroplasty for female urethral stricture disease.背侧阴道皮瓣尿道成形术治疗女性尿道狭窄疾病。
BJU Int. 2012 Dec;110(11 Pt C):E1090-5. doi: 10.1111/j.1464-410X.2012.11233.x. Epub 2012 May 17.
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