Liu T Y, Gotschlich E C, Egan W, Robbins J B
J Infect Dis. 1977 Aug;136 Suppl:S71-7. doi: 10.1093/infdis/136.supplement.s71.
A polysaccharide antigenically related to that of group C Neisseria meningitidis was isolated from Escherichia coli strain Bos-12 (O48: K91:NM). Like the polysaccharides of groups B and CN. meningitidis, the Bos-12 antigen was shown to be a pure polymer of sialic acid. The 13C-nuclear magnetic resonance studies of the groups B and C polysaccharides indicated that the former consists of units of sialic acid joined in alpha-2 leads to 8 linkages, whereas the latter contains sialic acid residues linked by alpha-2 leads to 9 glycosidic bonds. Chemical and nuclear magnetic resonance studies of the polysaccharide of E. coli strain Bos-12 established that it is a heteropolymer containing both alpha-2 leads to 8 and alpha-2 leads to 9 linkages. Physical parameters including partial specific volume, reduced viscosity, diffusion and sedimentation coefficients, shape, weight-average molecular weight, and the Stokes radius of the polysaccharides of groups A, B, and C N. meningitidis have been determined. The results indicate that the polysaccharides are highly asymmetric and exist in solution as rigid rods; aggregates are formed by the association of these rods. The polysaccharides appear to have "restricted" length.
从大肠杆菌Bos - 12菌株（O48:K91:NM）中分离出一种与C群脑膜炎奈瑟菌抗原相关的多糖。与B群和C群脑膜炎奈瑟菌的多糖一样，Bos - 12抗原被证明是唾液酸的纯聚合物。对B群和C群多糖的13C核磁共振研究表明，前者由通过α - 2→8连接的唾液酸单元组成，而后者含有通过α - 2→9糖苷键连接的唾液酸残基。对大肠杆菌Bos - 12菌株多糖的化学和核磁共振研究表明，它是一种含有α - 2→8和α - 2→9连接的杂聚物。已经测定了A群、B群和C群脑膜炎奈瑟菌多糖的物理参数，包括比容、比浓粘度、扩散系数和沉降系数、形状、重均分子量以及斯托克斯半径。结果表明，这些多糖高度不对称，在溶液中以刚性棒状存在；这些棒状分子缔合形成聚集体。这些多糖似乎具有“受限”长度。
