Andreev Dmitrii N, Khurmatullina Alsu R, Maev Igor V, Bordin Dmitry S, Abdulkhakov Sayar R, Kucheryavyy Yury A, Beliy Petr A, Sokolov Filipp S
Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia.
Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia.
Epidemiologia (Basel). 2025 Aug 12;6(3):47. doi: 10.3390/epidemiologia6030047.
The objective of this study is to assess the dynamics of infection prevalence among adults in Russia. A systematic search was conducted in MEDLINE/PubMed, EMBASE, Cochrane, RSCI, and Google Scholar for studies published between 1985 and 27 February 2025, following PRISMA guidelines. The meta-analysis was registered in PROSPERO (CRD420251011643). Twenty studies were included (n = 117,841; weighted mean age: 43.71 ± 16.23 years), all using validated diagnostic methods. The pooled prevalence from 1994 to 2024 was 62.847% (95% CI: 55.101-70.274), including 45.143% (95% CI: 41.390-48.923) by the C-urea breath test and 75.806% (95% CI: 64.213-85.742) by serology. Prevalence declined over time: it was 79.334% before 2005, 74.074% in 2006-2011, and 66.319% in 2012-2017, and it has been 42.949% since 2018. Meta-regression confirmed a significant decrease (coefficient: -3.773% per year, < 0.001). A significant decline in the prevalence of has been observed, however, it remains relatively high and requires continued efforts aimed at diagnosis and eradication.
本研究的目的是评估俄罗斯成年人感染率的动态变化。按照PRISMA指南，在MEDLINE/PubMed、EMBASE、Cochrane、RSCI和谷歌学术中对1985年至2025年2月27日发表的研究进行了系统检索。该荟萃分析已在PROSPERO（CRD420251011643）中注册。纳入了20项研究（n = 117,841；加权平均年龄：43.71 ± 16.23岁），所有研究均使用经过验证的诊断方法。1994年至2024年的合并感染率为62.847%（95%置信区间：55.101 - 70.274），其中碳-尿素呼气试验检测的感染率为45.143%（95%置信区间：41.390 - 48.923），血清学检测的感染率为75.806%（95%置信区间：64.213 - 85.742）。感染率随时间下降：2005年前为79.334%，2006 - 2011年为74.074%，2012 - 2017年为66.319%，自2018年以来为42.949%。荟萃回归证实感染率显著下降（系数：每年-3.773%，< 0.001）。已观察到感染率显著下降，然而，其仍相对较高，需要继续努力进行诊断和根除。
