Haukkamaa M, Gummerus M, Kleimola T
Br J Obstet Gynaecol. 1985 Dec;92(12):1230-3. doi: 10.1111/j.1471-0528.1985.tb04867.x.
The serum concentration of salbutamol was determined in 29 pregnant women during oral treatment (4 mg five times per day) and in seven during intravenous infusion (6-30 micrograms/min) because of premature labour. The concentration of salbutamol was determined by combined gas-liquid chromatography mass spectrometry. The mean concentration of serum salbutamol was twice as high during intravenous treatment (24; SD 9 ng/ml), than during oral treatment (12; SD 3 mg/ml). During oral treatment, the salbutamol levels were not correlated to maternal height, weight or the incidence or severity of side-effects. The serum concentrations of salbutamol in patients with twin pregnancies did not differ from those with singleton pregnancies. After stopping intravenous treatment, serum salbutamol levels remained high for several hours and oral treatment can be started 4-6 h after stopping intravenous infusion.
对29名接受口服治疗（每日5次，每次4毫克）的孕妇以及7名因早产接受静脉输注（6 - 30微克/分钟）的孕妇测定了沙丁胺醇的血清浓度。沙丁胺醇浓度通过气液色谱 - 质谱联用测定。静脉治疗期间血清沙丁胺醇的平均浓度（24；标准差9纳克/毫升）是口服治疗期间（12；标准差3毫克/毫升）的两倍。口服治疗期间，沙丁胺醇水平与产妇身高、体重或副作用的发生率或严重程度无关。双胎妊娠患者的血清沙丁胺醇浓度与单胎妊娠患者无异。停止静脉治疗后，血清沙丁胺醇水平在数小时内仍保持较高，停止静脉输注后4 - 6小时可开始口服治疗。
