Haukkamaa M, Gummerus M
Br J Obstet Gynaecol. 1982 Nov;89(11):917-20. doi: 10.1111/j.1471-0528.1982.tb05057.x.
Patients with premature labour were treated with intravenous hexoprenaline (18 patients) or salbutamol (10 patients) infusion between 26 and 36 weeks gestation. After at least 12 h infusion, oral therapy was started. Serum total oestriol was determined by radioimmunoassay every 6 h during intravenous beta-mimetic infusion (p less than 0.005). One day after stopping intravenous treatment, and then every day after stopping the infusion, for 4 days. The mean serum total oestriol concentration decreased significantly during the intravenous treatment, serum oestriol returned to pretreatment levels. The results show that fetal monitoring by maternal oestriol determinations is not reliable during intravenous beta-adrenoceptor agonist therapy.
早产患者在妊娠26至36周期间接受静脉注射己丙肾上腺素（18例患者）或沙丁胺醇（10例患者）治疗。静脉输注至少12小时后，开始口服治疗。在静脉注射β-拟交感神经药物期间，每6小时通过放射免疫测定法测定血清总雌三醇（p<0.005）。停止静脉治疗一天后，然后在停止输注后的每一天，持续4天。静脉治疗期间血清总雌三醇浓度显著下降，血清雌三醇恢复到治疗前水平。结果表明，在静脉注射β-肾上腺素能受体激动剂治疗期间，通过测定母体雌三醇进行胎儿监测并不可靠。
