正常妊娠时的Amerlex游离三碘甲状腺原氨酸和游离甲状腺素水平。

Amerlex free triiodothyronine and free thyroxine levels in normal pregnancy.

作者信息

Parker J H

出版信息

Br J Obstet Gynaecol. 1985 Dec;92(12):1234-8. doi: 10.1111/j.1471-0528.1985.tb04868.x.

DOI:10.1111/j.1471-0528.1985.tb04868.x

Abstract

Free triiodothyronine (FT3) and free thyroxine (FT4) were measured in 159 women during normal pregnancy and compared with non-pregnancy reference ranges for these hormones. FT3 values fell from the reference level of 6.34 (SD 1.06) pmol/l to 3.87 (SD 0.54) pmol/l in the 3rd trimester; corresponding figures for FT4 were: reference 16.92 (SD 2.97) pmol/l, 3rd trimester 11.29 (SD 2.01) pmol/l. There were no significant changes in the 1st trimester; 4% and 69% of FT3 results in the 2nd and 3rd trimesters respectively fell below the reference range of mean +/- 2 SD. The corresponding findings for FT4 were 4% and 42%. FT3 correlated reasonably well with total T3 (r = 0.90) and was acceptably precise (within-batch CV 2.1% at 5.6 pmol/l, between-batch CV between 3.1% and 4.7% at six levels).

摘要

对159名正常孕期女性测量了游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4），并将这些激素的测量值与非孕期参考范围进行了比较。孕晚期FT3值从参考水平6.34（标准差1.06）pmol/l降至3.87（标准差0.54）pmol/l；FT4的相应数据为：参考值16.92（标准差2.97）pmol/l，孕晚期11.29（标准差2.01）pmol/l。孕早期无显著变化；孕中期和孕晚期分别有4%和69%的FT3结果低于平均±2标准差的参考范围。FT4的相应结果分别为4%和42%。FT3与总T3相关性良好（r = 0.90），精密度可接受（5.6 pmol/l时批内变异系数为2.1%，六个水平下批间变异系数在3.1%至4.7%之间）。