转换为法西单抗可减轻新生血管性年龄相关性黄斑变性中的持续性视网膜下液和色素上皮脱离。

Switching to faricimab alleviates persistent subretinal fluid and pigment epithelial detachment in neovascular age-related macular degeneration.

作者信息

Maehara Yusuke, Notomi Shoji, Shiose Satomi, Fukuda Yosuke, Kiyohara Kohei, Kano Kumiko, Ishikawa Keijiro, Hisatomi Toshio, Sonoda Koh-Hei

机构信息

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Department of Ophthalmology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

出版信息

Jpn J Ophthalmol. 2025 Aug 22. doi: 10.1007/s10384-025-01264-6.

DOI:10.1007/s10384-025-01264-6

Abstract

PURPOSE

To evaluate structural outcomes, including subretinal fluid (SRF) and fibrovascular pigment epithelial detachment (fvPED) volume changes, after switching from aflibercept 2 mg to faricimab in Japanese patients with neovascular age-related macular degeneration (nAMD).

STUDY DESIGN

Retrospective, observational study.

METHODS

Patients with nAMD who were switched from aflibercept 2 mg to faricimab were enrolled. Changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), and the volumes of SRF and fvPED were analyzed using three-dimensional spectral-domain optical coherence tomography data.

RESULTS

A total of 46 eyes from 46 patients were included. All had been maintained on fixed dosing due to difficulty in extending the injection interval. Patients had received a mean of 25.6 aflibercept 2 mg injections, with a mean interval of 7.5 weeks for the last three injections. Subsequently, three faricimab injections were given at similar intervals (7.6 weeks). BCVA remained unchanged (p = 0.066), while CMT, SRF, and fvPED volumes significantly decreased (p < 0.01). A significant correlation was found between the reductions in SRF and fvPED volumes (p < 0.05).

CONCLUSIONS

Switching to faricimab led to favorable structural outcomes in nAMD patients previously treated with aflibercept 2 mg, particularly by reducing SRF and fvPED.

摘要

目的

评估日本新生血管性年龄相关性黄斑变性（nAMD）患者从阿柏西普2mg转换为法西单抗后包括视网膜下液（SRF）和纤维血管性色素上皮脱离（fvPED）体积变化在内的结构结果。

研究设计

回顾性观察研究。

方法

纳入从阿柏西普2mg转换为法西单抗的nAMD患者。使用三维光谱域光学相干断层扫描数据分析最佳矫正视力（BCVA）、中心黄斑厚度（CMT）以及SRF和fvPED体积的变化。

结果

共纳入46例患者的46只眼。由于难以延长注射间隔，所有患者均维持固定剂量给药。患者平均接受了25.6次阿柏西普2mg注射，最后三次注射的平均间隔为7.5周。随后，以相似间隔（7.6周）给予三次法西单抗注射。BCVA保持不变（p = 0.066），而CMT、SRF和fvPED体积显著降低（p < 0.01）。发现SRF和fvPED体积减少之间存在显著相关性（p < 0.05）。

结论

转换为法西单抗在先前接受阿柏西普2mg治疗的nAMD患者中产生了良好的结构结果，特别是通过减少SRF和fvPED。