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与接受异基因和自体干细胞移植及嵌合抗原受体疗法(CAR-T)的患者进行的健康相关价值观讨论:早期由执业护士主导的初级姑息治疗干预措施的实施

Health-Related Values Discussions With Patients Receiving Allogeneic and Autologous Stem Cell Transplant and Chimeric Antigen Receptor Therapy (CAR-T): Implementation of an Early Nurse Practitioner-Led Primary Palliative Care Intervention.

作者信息

Cohen Abigail G, Kramer Dana, Mazzarella Kathryn, Scott Megan H, Szkolnicki Mia, Tucker Alli, Qualters Kelley, Perales Miguel-Angel, Brooklyn Chelsea, Epstein Andrew S, Nelson Judith E, Lestrange Nicole

机构信息

Abigail G. Cohen, MSc, ANP-BC, AOCNP, BMTCN, is a Nurse Practitioner, BMT/CAR-T Survivorship Program, Memorial Sloan Kettering Cancer Center, New York, NY.

Dana Kramer, MSc, ANP-BC, is a Nurse Practitioner, Supportive Care Service, Memorial Sloan Kettering Cancer Center, New York, NY.

出版信息

J Hosp Palliat Nurs. 2025 Aug 22. doi: 10.1097/NJH.0000000000001148.

DOI:10.1097/NJH.0000000000001148
PMID:40845273
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12380123/
Abstract

Patients undergoing hematopoietic stem cell transplant and chimeric antigen receptor-T cell therapy face significant uncertainty, distress, risk of serious treatment-related complications, and disease relapse. Although palliative care and advance care planning offer clear benefits, both remain underutilized or delayed in this patient population. To address this gap, a nurse practitioner (NP)-led primary palliative care intervention was implemented in the outpatient Bone Marrow Transplant and Cellular Therapy Services at a comprehensive cancer center. This paper provides an overview of the program model, involving NP-led health-related values and care preferences discussions with patients and their families. This highlights the pivotal role of NPs in delivering primary palliative care by integrating values-based discussions into routine oncology practice. Future goals include evaluating the intervention's impact on patient and caregiver outcomes, clinician understanding, care alignment with patient's goals, advance directive completion, and high-intensity care at the end of life.

摘要

接受造血干细胞移植和嵌合抗原受体T细胞疗法的患者面临着巨大的不确定性、痛苦、严重治疗相关并发症的风险以及疾病复发。尽管姑息治疗和预先护理计划有明显益处,但在这一患者群体中,两者的使用仍然不足或延迟。为了弥补这一差距,在一家综合癌症中心的门诊骨髓移植和细胞治疗服务部门实施了一项由执业护士主导的初级姑息治疗干预措施。本文概述了该项目模式,包括由执业护士主导的与患者及其家属进行的与健康相关的价值观和护理偏好讨论。这突出了执业护士在将基于价值观的讨论融入常规肿瘤学实践以提供初级姑息治疗方面的关键作用。未来的目标包括评估该干预措施对患者和护理人员结局、临床医生理解、护理与患者目标的一致性、预先医疗指示的完成情况以及临终时的高强度护理的影响。

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本文引用的文献

1
Mitigation and Management of Common Toxicities Associated with the Administration of CAR-T Therapies in Oncology Patients.肿瘤患者接受CAR-T疗法相关常见毒性的缓解与管理
Drug Saf. 2025 Mar 19. doi: 10.1007/s40264-025-01538-5.
2
Nursing-Led Early Palliative Care Referrals for Patients Receiving Chimeric Antigen Receptor T-Cell Therapy.为接受嵌合抗原受体T细胞疗法的患者提供由护士主导的早期姑息治疗转诊服务。
Clin J Oncol Nurs. 2025 Jan 17;29(1):36-41. doi: 10.1188/25.CJON.36-41.
3
Health-Related Values Discussions with Patients Undergoing Allogeneic and Autologous Stem Cell Transplant: Feasibility and Acceptability of an Early Primary Palliative Care Intervention.与接受同种异体和自体干细胞移植的患者进行的健康相关价值观讨论:早期初级姑息治疗干预的可行性和可接受性。
Transplant Cell Ther. 2025 Feb;31(2):107.e1-107.e12. doi: 10.1016/j.jtct.2024.12.009. Epub 2024 Dec 17.
4
Promoting patient-centered care in CAR-T therapy for hematologic malignancy: a qualitative meta-synthesis.促进 CAR-T 疗法治疗血液恶性肿瘤中的以患者为中心的护理:定性元分析。
Support Care Cancer. 2024 Aug 16;32(9):591. doi: 10.1007/s00520-024-08799-3.
5
Specialized palliative care in patients with haematological malignancies receiving chimeric antigen receptor T-cell therapy.接受嵌合抗原受体T细胞疗法的血液系统恶性肿瘤患者的专科姑息治疗
Br J Haematol. 2024 Jul;205(1):343-346. doi: 10.1111/bjh.19434. Epub 2024 Mar 24.
6
Patient and Clinician Stakeholder Perspectives on a Patient Portal Questionnaire Eliciting Illness and Treatment Understanding and Core Health-Related Values.患者和临床医生利益相关者对一份患者门户网站问卷的看法,该问卷旨在了解疾病和治疗情况以及核心健康相关价值观。
Palliat Med Rep. 2023 Nov 30;4(1):316-325. doi: 10.1089/pmr.2023.0057. eCollection 2023.
7
Integrated Palliative Care for Patients Referred for Chimeric Antigen Receptor (CAR) T-Cell Therapy: A Service Evaluation.嵌合抗原受体(CAR)T细胞治疗转诊患者的综合姑息治疗:一项服务评估。
J Pain Symptom Manage. 2024 Feb;67(2):e157-e159. doi: 10.1016/j.jpainsymman.2023.11.002. Epub 2023 Nov 8.
8
Early cytopenias and infections following chimeric antigen receptor T-Cell therapy for hematologic malignancies.嵌合抗原受体T细胞疗法治疗血液系统恶性肿瘤后的早期血细胞减少和感染
Leuk Lymphoma. 2023 Sep;64(9):1592-1595. doi: 10.1080/10428194.2023.2220455. Epub 2023 Jun 7.
9
End of life in haematology: quality of life predictors - retrospective cohort study.血液学中的生命末期:生活质量预测因素 - 回顾性队列研究
BMJ Support Palliat Care. 2024 Dec 19;14(e3):e2708-e2718. doi: 10.1136/spcare-2023-004218.
10
Quality of Life, Physical Functioning, and Psychological Distress of Older Adults Undergoing Hematopoietic Stem Cell Transplantation.老年造血干细胞移植患者的生活质量、身体功能和心理困扰。
Transplant Cell Ther. 2023 Jun;29(6):387.e1-387.e7. doi: 10.1016/j.jtct.2023.03.017. Epub 2023 Mar 22.