Cimen Yasin Ali, Taslidere Bahadir, Sarikaya Ufuk, Demirel Metin, Acikgoz Nusret, Selek Sahabettin
Department of Physiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Department of Emergency Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Clinics (Sao Paulo). 2025 Aug 21;80:100755. doi: 10.1016/j.clinsp.2025.100755.
Acute Myocardial Infarction (AMI) and Heart Failure (HF) are the leading global causes of death from Cardiovascular Diseases (CVD). This study aimed to investigate the association of serum Zinc (Zn), Copper (Cu), and thiol levels with CVD and new potential biomarkers.
The study included serum samples from 150 participants, including 50 AMI patients, 50 HF patients, and 50 healthy individuals. Oxidative stress, trace elements (Cu and Zn), and thiol levels were investigated by automated kits in AMI and HF patients compared to the control group.
T-thiol, N-thiol and Cu levels were higher in the AMI group than in the control group (p < 0.05, p < 0.01, p < 0.01, respectively). Cu and Zn levels were higher in the HF group compared to the control group (p < 0.001, p < 0.01, respectively). Compared to the HF group, T-thiol (p < 0.05), N-thiol (p < 0.05), and Zn (p < 0.001) levels were higher in the AMI group. By ROC analysis, Zn, Cu and thiol levels showed moderate discriminative power, emphasizing their candidacy as biomarkers.
Despite the limitations of age-related variations and sample size, this study pioneers the comparative analysis of AMI and HF, contributing to the elucidation of the complex connections between Zn, Cu and thiol levels in cardiovascular pathologies. It increases the importance of Zn, Cu and thiol levels in CVD's status, necessitating further research on this topic with refined methodologies.
急性心肌梗死（AMI）和心力衰竭（HF）是全球心血管疾病（CVD）导致死亡的主要原因。本研究旨在调查血清锌（Zn）、铜（Cu）和硫醇水平与心血管疾病及新的潜在生物标志物之间的关联。
该研究纳入了150名参与者的血清样本，包括50名AMI患者、50名HF患者和50名健康个体。与对照组相比，采用自动试剂盒对AMI和HF患者的氧化应激、微量元素（Cu和Zn）以及硫醇水平进行了检测。
AMI组的总硫醇（T-硫醇）、非蛋白硫醇（N-硫醇）和Cu水平高于对照组（分别为p < 0.05、p < 0.01、p < 0.01）。HF组的Cu和Zn水平高于对照组（分别为p < 0.001、p < 0.01）。与HF组相比，AMI组的T-硫醇（p < 0.05）、N-硫醇（p < 0.05）和Zn（p < 0.001）水平更高。通过ROC分析，Zn、Cu和硫醇水平显示出中等判别能力，强调了它们作为生物标志物的可能性。
尽管存在与年龄相关的差异和样本量的局限性，但本研究率先对AMI和HF进行了比较分析，有助于阐明心血管疾病中Zn、Cu和硫醇水平之间的复杂联系。它增加了Zn、Cu和硫醇水平在心血管疾病状况中的重要性，有必要采用更精细的方法对该主题进行进一步研究。
