Zhu Zixin, Liu Laiyi, Xie Qingyun, Chen Song, Sun Yiwan, Huang Chenjun, Lee Kyu-Jae, Gou Xue, Li Xiaohong
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China; Department of Orthopedics, General Hospital of Western Theater Command, Chengdu, Sichuan 610031, China; Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China; Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.
Acta Biomater. 2025 Sep 15;204:354-370. doi: 10.1016/j.actbio.2025.08.033. Epub 2025 Aug 20.
Smart wound management remains a significant challenge, necessitating real-time monitoring and dynamic treatment. Herein, an innovative multifunctional Janus dressing is designed to enable sustainable pH sensing, and provide dynamic drug delivery and electrical therapy at infected wounds. Specifically, the hydrophilic side is a pH-sensing layer with phenol red grafted onto amino-modified poly (2-hydroxyethyl methacrylate) via Mannich reaction, while the hydrophobic side contains drug-loaded piezoelectric particles semi-embedded in a polydimethylsiloxane matrix for therapeutic delivery. The dressing exhibits high flexibility (156 % elongation), strong water absorption (123 %), rapid pH sensing (∼1.5 min), and controllable piezoelectricity. Upon application, wound exudates are autonomously pumped through micropores to the hydrophilic layer, signaling infection, triggering drug release and "high electric field" treatment via external ultrasound, achieving an antibacterial treatment with a rate of up to 97.5 %. Following antimicrobial treatment, natural body movements and skin tension exert mechanical loading on the dressing, facilitating self-powered "low electric field" stimulation for tissue repair. The smart wound management effectively detects wound infection and delivers dynamic, adaptive electrotherapy, reducing inflammatory responses, accelerating collagen deposition, and enhancing tissue regeneration. This study presents a promising approach for advancing integrated wound dressings that unify diagnosis and therapy. STATEMENT OF SIGNIFICANCE: A multifunctional Janus dressing was developed to benefit sustainable pH sensing, and enable drug delivery alongside dynamic electrotherapy. Upon application, wound exudate was automatically drawn through micropores into the hydrophilic layer, triggering the release of an infection signal that initiates drug release. Subsequently, antibacterial treatment was administered via a high electric field facilitated by external ultrasound. Following antibacterial therapy, a self-powered low electric field promoted tissue regeneration. The dressing exhibited 156 % elongation, 123 % water absorption, and a rapid pH response (∼1.5 min). Both in vitro and in vivo studies demonstrated that this strategy significantly accelerated wound healing, establishing a smart system for personalized wound management.
智能伤口管理仍然是一项重大挑战，需要实时监测和动态治疗。在此，设计了一种创新的多功能双面敷料，以实现可持续的pH传感，并在感染伤口处提供动态药物递送和电疗法。具体而言，亲水侧是通过曼尼希反应将酚红接枝到氨基改性聚（甲基丙烯酸2-羟乙酯）上的pH传感层，而疏水侧包含半嵌入聚二甲基硅氧烷基质中的载药压电颗粒，用于治疗递送。该敷料具有高柔韧性（伸长率156%）、强吸水性（123%）、快速pH传感（约1.5分钟）和可控压电性。应用时，伤口渗出液通过微孔自动泵送到亲水层，发出感染信号，通过外部超声触发药物释放和“高电场”治疗，实现高达97.5%的抗菌治疗率。抗菌治疗后，身体的自然运动和皮肤张力对敷料施加机械负荷，促进自供电的“低电场”刺激以促进组织修复。智能伤口管理有效地检测伤口感染并提供动态、自适应电疗法，减少炎症反应，加速胶原蛋白沉积，并增强组织再生。本研究提出了一种推进统一诊断和治疗的集成伤口敷料的有前景的方法。重要性声明：开发了一种多功能双面敷料，以实现可持续的pH传感，并在动态电疗法的同时实现药物递送。应用时，伤口渗出液通过微孔自动吸入亲水层，触发感染信号的释放，从而启动药物释放。随后，通过外部超声促进的高电场进行抗菌治疗。抗菌治疗后，自供电的低电场促进组织再生。该敷料的伸长率为156%，吸水率为123%，pH响应迅速（约1.5分钟）。体外和体内研究均表明，该策略显著加速了伤口愈合，建立了一个用于个性化伤口管理的智能系统。
