Luo Yang, Li Shiqi, Ding Yan, Shi Shasha
Department of Cardiovascular Medicine, Zhejiang Province Wuyi County First People's Hospital, Jinhua, Zhejiang, China.
Department of Clinical Laboratory, Ningbo No.9 Hospital, Ningbo, Zhejiang, China.
BMC Med Genomics. 2025 Aug 23;18(1):136. doi: 10.1186/s12920-025-02167-8.
Inflammatory cytokines are pivotal in the pathophysiology of acute coronary syndrome (ACS) and have been associated with major adverse cardiovascular events. In this study, we aimed to assess the association of eight polymorphisms in IL-10, IL-6, and TNF-α with the risk of ACS through a systematic review, meta-analysis, and trial sequential analysis. A comprehensive literature review was conducted across multiple databases, including PubMed/Medline, Web of Science, Scopus, and Cochrane Library, up until August 8, 2024. The Review Manager 5.3 software was utilized to compute the effect sizes such as the odds ratio accompanied by a 95% confidence interval. Out of 1499 records identified from databases, sources, or electronic searches, 51 articles were included in qualitative and quantitative syntheses (meta-analysis). For IL-6 -174G > C, the allelic and homozygous models showed significant associations with ACS risk. IL-6 -572G > C showed no significant association across all genetic models. IL-10 polymorphisms (-592C > A, -819C > T, and -1082A > G) generally showed no significant associations. TNF-α -308G > A polymorphism showed significant associations in all models. TNF-α -1031T > C and -238G > A showed no significant associations, with varying degrees of heterogeneity. Results suggest that certain cytokine polymorphisms, notably IL-6 -174G > C and TNF-α -308G > A, may play a crucial role in increasing susceptibility to ACS. These associations are especially pronounced in certain ethnic groups, such as Asians and Arabs, highlighting the importance of considering genetic diversity in clinical assessments.
炎症细胞因子在急性冠状动脉综合征（ACS）的病理生理学中起关键作用，并与主要不良心血管事件相关。在本研究中，我们旨在通过系统评价、荟萃分析和试验序贯分析，评估白细胞介素-10（IL-10）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的8种多态性与ACS风险的关联。截至2024年8月8日，我们在多个数据库中进行了全面的文献检索，包括PubMed/Medline、Web of Science、Scopus和Cochrane图书馆。使用Review Manager 5.3软件计算效应大小，如比值比及95%置信区间。从数据库、来源或电子检索中识别出的1499条记录中，有51篇文章纳入了定性和定量综合分析（荟萃分析）。对于IL-6 -174G＞C，等位基因模型和纯合子模型显示与ACS风险存在显著关联。IL-6 -572G＞C在所有遗传模型中均未显示出显著关联。IL-10多态性（-592C＞A、-819C＞T和-1082A＞G）通常未显示出显著关联。TNF-α -308G＞A多态性在所有模型中均显示出显著关联。TNF-α -1031T＞C和-238G＞A未显示出显著关联，存在不同程度的异质性。结果表明，某些细胞因子多态性，特别是IL-6 -174G＞C和TNF-α -308G＞A，可能在增加ACS易感性方面起关键作用。这些关联在某些种族群体中尤为明显，如亚洲人和阿拉伯人，凸显了在临床评估中考虑遗传多样性的重要性。
