Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2024 Oct;262:155561. doi: 10.1016/j.prp.2024.155561. Epub 2024 Aug 27.
Alcohol drinking is a major risk factor for head and neck cancer (HNC), and this risk may be modified by alcohol dehydrogenase (ADH) genes. The first systematic review and meta-analysis was designed with more studies and added trial sequential analysis and functional analysis for a better understanding of the role of ADH3 polymorphism in HNC patients.
A search was performed across several databases, including PubMed/Medline, Web of Science, Scopus, and Cochrane Library, up to May 5, 2024, without any restrictions to find pertinent studies. The RevMan 5.3 software was used to calculate the effect sizes. These were expressed as the odds ratio (OR) with a 95 % confidence interval.
Twenty-seven articles were included in the meta-analysis. The frequency of *1/*1, *1/*2, and *2/*2 genotypes in cases with HNC was 47.14 %, 41.06 %, and 11.80 %, respectively, and in controls was 50.56 %, 38.29 %, and 11.15 %, respectively. The pooled OR for the allelic model is 1.11 (p = 0.18), for the homozygous model is 0.95 (p = 0.64), for the heterozygous model is 0.99 (p = 0.90), for the dominant model is 1.11 (p = 0.14), and for the recessive model is 0.98 (p = 0.78). In the Asians, the three models showed an increased significant association. In the cancer subtype subgroup, a protective significant association was found in the pharyngeal cancer subtype.
The current analysis suggests that ADH3 polymorphism may not have a significant impact on the risk of HNC, but the polymorphism had an increased risk in Asians and a protective role in pharyngeal cancers.
饮酒是头颈部癌症（HNC）的一个主要危险因素，而这种风险可能会因醇脱氢酶（ADH）基因而改变。本研究进行了首次系统的综述和荟萃分析，纳入了更多的研究，并增加了试验序贯分析和功能分析，以便更好地了解 ADH3 多态性在 HNC 患者中的作用。
本研究无任何限制地在多个数据库（包括 PubMed/Medline、Web of Science、Scopus 和 Cochrane Library）中进行了检索，检索时间截至 2024 年 5 月 5 日，以查找相关研究。使用 RevMan 5.3 软件计算效应量。这些效应量表示为比值比（OR）及其 95%置信区间。
共有 27 篇文章纳入荟萃分析。HNC 病例中*1/*1、*1/2 和2/*2 基因型的频率分别为 47.14%、41.06%和 11.80%，而对照组分别为 50.56%、38.29%和 11.15%。等位基因模型的合并 OR 为 1.11（p=0.18），纯合模型为 0.95（p=0.64），杂合模型为 0.99（p=0.90），显性模型为 1.11（p=0.14），隐性模型为 0.98（p=0.78）。在亚洲人群中，三种模型均显示出显著的相关性。在癌症亚型亚组中，发现咽癌亚型存在保护性显著相关性。
目前的分析表明，ADH3 多态性可能不会显著影响 HNC 的风险，但在亚洲人群中，多态性会增加风险，在咽癌中具有保护作用。
