Sanders E A, Reulen J P, Hogenhuis L A, van der Velde E A
Can J Neurol Sci. 1985 Nov;12(4):308-13. doi: 10.1017/s0317167100035393.
Visual evoked response (VER), auditory brainstem evoked response (ABER), somatosensory evoked response (SSER), blink reflex and electronystagmographic (ENG) investigative methods were applied to a group of 89 patients with Multiple Sclerosis (MS) and Optic Neuritis (ON). The MS patients were classified as definite (n = 31), probable (n = 31) and possible (n = 27). The aim of this study was to determine the diagnostic value of the five electrophysiological tests in MS. VER and ABER recordings were found to reveal the highest number of asymptomatic abnormalities (33 and 31 percent respectively). The combination of VER, ABER and ENG revealed all possible electrophysiological disorders. As these tests are completely non-invasive it is proposed, that a combination of two of these three tests is useful for the detection of a second silent lesion in patients with suspected MS showing purely spinal signs (VER, ENG, ABER) and/or a history of uncomplicated ON (ABER, ENG).
对89例多发性硬化症（MS）和视神经炎（ON）患者应用了视觉诱发电位（VER）、听觉脑干诱发电位（ABER）、体感诱发电位（SSER）、眨眼反射和眼震电图（ENG）检查方法。MS患者分为确诊组（n = 31）、疑似组（n = 31）和可能组（n = 27）。本研究的目的是确定这五项电生理检查对MS的诊断价值。发现VER和ABER记录显示无症状异常的比例最高（分别为33%和31%）。VER、ABER和ENG联合检查可发现所有可能的电生理紊乱。由于这些检查完全无创，因此建议，对于表现为单纯脊髓体征（VER、ENG、ABER）和/或无并发症ON病史（ABER、ENG）的疑似MS患者，这三项检查中的两项联合使用有助于检测第二个无症状病灶。
