脑干在多发性硬化中的受累情况：一项临床与电生理研究。

Brainstem involvement in multiple sclerosis: a clinical and electrophysiological study.

作者信息

Sanders E A, Reulen J P, Hogenhuis L A, van der Velde E A

出版信息

Acta Neurol Scand. 1985 Jan;71(1):54-61. doi: 10.1111/j.1600-0404.1985.tb03167.x.

DOI:10.1111/j.1600-0404.1985.tb03167.x

Abstract

A major aim of this study was to determine the diagnostic value of 4 electrophysiological tests in MS, and particularly their effectiveness in detecting signs of brainstem involvement. Therefore, auditory brainstem evoked response (ABER), somatosensory evoked response (SSER), blink reflex and electronystagmographic (ENG) investigative methods were applied to a group of 89 patients with definite, probable or possible multiple sclerosis (MS). The 4 methods yielded interdependent data, especially where the brainstem function was concerned, thus it can be concluded that a single demyelinating lesion may cause a combination of electrophysiological disorders within a small structure such as the brainstem. ENG recordings were found to reveal the highest number of asymptomatic abnormalities. The combination of ABER and ENG tests revealed electrophysiological disorders in 81% of all patients. The blink reflex and the SSER tests gave hardly supplementary information.

摘要

本研究的一个主要目的是确定4种电生理测试在多发性硬化症（MS）中的诊断价值，尤其是它们在检测脑干受累迹象方面的有效性。因此，对89例确诊、可能或疑似多发性硬化症（MS）患者应用了听觉脑干诱发电位（ABER）、体感诱发电位（SSER）、眨眼反射和眼震电图（ENG）检查方法。这4种方法产生了相互依赖的数据，尤其是在脑干功能方面，因此可以得出结论，单个脱髓鞘病变可能会在脑干这样的小结构内导致电生理紊乱的组合。发现ENG记录显示无症状异常的数量最多。ABER和ENG测试相结合，在所有患者中发现81%存在电生理紊乱。眨眼反射和SSER测试几乎没有提供补充信息。