Young G B, Blume W T, Wells G A, Mertens W C, Eder S
Can J Neurol Sci. 1985 Nov;12(4):317-20. doi: 10.1017/s0317167100035411.
A review of patients with epilepsy showed that 5.9% had seizures exclusively in sleep (ES) and 4.7% had seizures predominantly but not exclusively in sleep (PS). These groups were compared with a group (W) with seizures mainly in wakefulness. The following significant differences were obtained: 1) generalized convulsions predominated in the ES while partial seizures were more common among PS and W patients, 2) seizures occurred less frequently in the ES group, and 3) more W patients had EEGs with generalized epileptiform activity and positive family histories for epilepsy. We suggest the lower frequency of seizures in the ES group and the declining prevalence of sleep epilepsy are due to: 1) the high proportion of generalized as opposed to partial seizures in sleep and 2) more effective control of generalized seizures compared to partial seizures by modern anti-epileptic drug management.
一项对癫痫患者的回顾性研究表明，5.9%的患者仅在睡眠中发作（ES），4.7%的患者主要但并非仅在睡眠中发作（PS）。将这些组与主要在清醒时发作的一组（W）进行比较。得出以下显著差异：1）ES组中全身性惊厥占主导，而PS组和W组患者中部分性发作更为常见；2）ES组发作频率较低；3）更多W组患者的脑电图有全身性癫痫样活动且有癫痫家族史阳性。我们认为ES组发作频率较低以及睡眠性癫痫患病率下降的原因是：1）睡眠中全身性发作与部分性发作的比例较高；2）与部分性发作相比，现代抗癫痫药物治疗对全身性发作的控制更有效。
