松鼠猴（松鼠猴属）胎盘及胎盘培养物中的类肿瘤病毒颗粒

Oncornavirus-like particles in squirrel monkey (Saimiri sciureus) placenta and placenta culture.

作者信息

Smith G C, Heberling R L, Helmke R J, Barker S T, Kalter S S

出版信息

J Natl Cancer Inst. 1977 Sep;59(3):975-9. doi: 10.1093/jnci/59.3.975.

DOI:10.1093/jnci/59.3.975

Abstract

Oncornavirus-like particles similar in morphology to type D particles were observed in 1 of 2 squirrel monkey (Saimiri sciureus) placentas. Intracytoplasmic type A particles, immature virus particles, and mature viruses with eccentric or occasionally centric nucleoids were associated with placental syncytiotrophoblasts. A spike layer typical of type B viruses was not detected in viral envelopes. Onvornaviruses, identical to those previously isolated from squirrel monkey tissues and similar to Mason-Pfizer monkey virus, were seen in cultures derived from the virus-positive squirrel monkey placenta cocultivated with a mink lung culture. The major morphologic difference between the in vivo and the in vitro squirrel monkey virus was in the nucleoid position of mature virus particles.

摘要

在2只松鼠猴（松鼠猴属）胎盘的其中1个中观察到形态与D型颗粒相似的类肿瘤病毒样颗粒。胞质内A型颗粒、未成熟病毒颗粒以及带有偏心或偶尔中心状核仁的成熟病毒与胎盘合体滋养层细胞相关。在病毒包膜中未检测到典型的B型病毒刺突层。在与貂肺培养物共培养的病毒阳性松鼠猴胎盘来源的培养物中，发现了与先前从松鼠猴组织中分离出的病毒相同且与梅森 - 辉瑞猴病毒相似的肿瘤病毒。体内和体外松鼠猴病毒之间的主要形态学差异在于成熟病毒颗粒的核仁位置。