Albert D M
Trans Am Ophthalmol Soc. 1979;77:367-421.
Electron microscopic examination of 57 ocular melanomas (54 human, two feline and one canine) revealed the presence of viral particles in six specimens. Herpesviruses particles were observed in one human specimen and were passed in human fibroblasts (WI-38), where they gave rise to intranuclear inclusions. A-type oncornavirus particles (oncogenic RNA virus) were observed in a second case, both in cells of tumor directly removed from an enucleated eye as well as in cells grown in tissue culture. In three human specimens and one feline specimen, togavirus particles were observed. Rubella is a member of this group, and the possibility that the presence of togavirus in these tumors is the result of latent ocular infection by rubella virus is raised. Herpes virus and RNA tumor viruses are widely considered as having a possible etiologic role for certain human cancers. The observation of togavirus is unexpected, as this virus has not been previously implicated in human or animal tumors. Injection of an RNA tumor virus (Gardner strain feline sarcoma virus) into the anterior chamber of newborn kittens resulted in the development of iris and ciliary body melanomas, many of which showed invasion and, in one instance, metastasis. This is the first animal model of a viral-induced uveal melanoma, and the histology and ultrastructure are described. These results emphasize the need for the continued investigation of the role of these viruses in uveal melanoma.
对57例眼黑色素瘤（54例人类、2例猫和1例犬）进行电子显微镜检查，发现6个标本中存在病毒颗粒。在1例人类标本中观察到疱疹病毒颗粒，并将其接种于人类成纤维细胞（WI-38），这些细胞中出现了核内包涵体。在第2例中观察到A型肿瘤病毒颗粒（致癌RNA病毒），在直接从摘除眼球中取出的肿瘤细胞以及组织培养中生长的细胞中均有发现。在3例人类标本和1例猫标本中观察到披膜病毒颗粒。风疹是该病毒组的成员之一，因此提出这些肿瘤中披膜病毒的存在可能是风疹病毒潜伏性眼部感染的结果。疱疹病毒和RNA肿瘤病毒被广泛认为可能在某些人类癌症中具有病因学作用。披膜病毒的观察结果出乎意料，因为该病毒此前未被认为与人类或动物肿瘤有关。将一种RNA肿瘤病毒（加德纳株猫肉瘤病毒）注入新生小猫的前房，导致虹膜和睫状体黑色素瘤的发生，其中许多肿瘤显示有浸润，在1例中还出现了转移。这是病毒诱导的葡萄膜黑色素瘤的首个动物模型，并对其组织学和超微结构进行了描述。这些结果强调了继续研究这些病毒在葡萄膜黑色素瘤中作用的必要性。
