Mareş Nicoleta Alina, Iordache Alexandru, Poalelungi Cristian Viorel, Costache Diana Alexandra, Georgescu Dragoş Adrian, Iordache Niculae
Doctoral School, Department of Obstetrics and Gynecology, Dr. I. Cantacuzino Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;
Rom J Morphol Embryol. 2025 Apr-Jun;66(2):405-410. doi: 10.47162/RJME.66.2.15.
Adenomatoid tumors (ATs) of the Fallopian tube are rare benign neoplasms, accounting for approximately 0.5-1% of all ATs of the female genital tract. They are often asymptomatic and discovered incidentally. Due to their mesothelial origin, histopathological (HP) diagnosis may be uncertain, requiring immunohistochemical (IHC) tests for definitive confirmation.
We present a case of an incidentally discovered tubal AT following a total hysterectomy with prophylactic salpingectomy in a 42-year-old patient with known uterine leiomyomatosis. IHC tests showed positive expression for calretinin and Wilms tumor 1 (WT1) and negative expression for Ki67 and p53, confirming the histological diagnosis of a tubal AT and ruling out malignancy.
This study highlights the asymptomatic nature of tubal ATs and emphasizes that they do not require specific treatment, and surgical excision is sufficient. Their HP appearance, combined with IHC findings, remains the key to diagnosis.
输卵管腺瘤样瘤（ATs）是罕见的良性肿瘤，约占女性生殖道所有ATs的0.5 - 1%。它们通常无症状，多为偶然发现。因其起源于间皮，组织病理学（HP）诊断可能不明确，需要免疫组织化学（IHC）检测来明确确诊。
我们报告一例42岁已知患有子宫平滑肌瘤病的患者，在全子宫切除加预防性输卵管切除术后偶然发现的输卵管AT。免疫组织化学检测显示钙视网膜蛋白和威尔姆斯瘤1（WT1）呈阳性表达，Ki67和p53呈阴性表达，证实了输卵管AT的组织学诊断并排除了恶性肿瘤。
本研究强调了输卵管ATs的无症状性质，并强调它们不需要特殊治疗，手术切除即可。其HP表现结合免疫组织化学结果仍然是诊断的关键。
