Jiao Hao, Wang Xiuying, Zhang Dahui, Zhou Shengxue, Gao Feng
College of Chinese Medicine, Jilin Agricultural Science and Technology College, Jilin, China.
Dehui Employment Training Center, Dehui, Jilin, China.
Front Aging Neurosci. 2025 Aug 7;17:1592280. doi: 10.3389/fnagi.2025.1592280. eCollection 2025.
Aging and neurodegenerative diseases are characterized by cognitive decline, impaired neuroplasticity, and epigenetic dysregulation. Curcumin, a bioactive polyphenol derived from , has gained significant attention for its neuroprotective properties, particularly in enhancing cognitive function through epigenetic mechanisms. This review explores the multifaceted role of curcumin in modulating key molecular pathways involved in neuroplasticity, including histone modifications, DNA methylation, and non-coding RNA regulation. Additionally, curcumin influences neurogenesis, synaptic remodeling, and mitochondrial biogenesis, which are critical for maintaining brain function in aging and neurodegenerative conditions such as Alzheimer's and Parkinson's disease. By targeting neuroinflammatory and oxidative stress pathways, curcumin further supports cognitive resilience and neuronal survival. We also discuss the therapeutic implications of curcumin as a potential epigenetic modulator and neurogenic agent, emphasizing its synergistic effects with lifestyle interventions such as physical activity and dietary strategies. Despite promising preclinical and clinical findings, challenges related to curcumin's bioavailability and translational efficacy remain. Future research should focus on optimizing delivery systems and exploring combination therapies to enhance curcumin's neuroprotective benefits. This review highlights curcumin as a promising candidate for promoting cognitive longevity and mitigating neurodegeneration through epigenetic reprogramming.
衰老和神经退行性疾病的特征是认知能力下降、神经可塑性受损和表观遗传失调。姜黄素是一种从 中提取的生物活性多酚，因其神经保护特性而备受关注，尤其是通过表观遗传机制增强认知功能。本综述探讨了姜黄素在调节神经可塑性相关关键分子途径中的多方面作用，包括组蛋白修饰、DNA甲基化和非编码RNA调控。此外，姜黄素影响神经发生、突触重塑和线粒体生物合成，这些对于在衰老以及阿尔茨海默病和帕金森病等神经退行性疾病状态下维持脑功能至关重要。通过靶向神经炎症和氧化应激途径，姜黄素进一步支持认知恢复力和神经元存活。我们还讨论了姜黄素作为潜在的表观遗传调节剂和神经发生剂的治疗意义，强调其与体育活动和饮食策略等生活方式干预的协同作用。尽管临床前和临床研究结果很有前景，但与姜黄素的生物利用度和转化疗效相关的挑战仍然存在。未来的研究应侧重于优化给药系统并探索联合疗法，以增强姜黄素的神经保护益处。本综述强调姜黄素是通过表观遗传重编程促进认知长寿和减轻神经退行性变的有希望的候选物。
