Erraoui Islam, Ech-Chebab Mohammed, Ayyad Anass, Messaoudi Sahar, Amrani Rim
Department of Pediatrics, University Hospital Center of Mohammed VI, Faculty of Medicine and Pharmacy, Mohammed Premier University, Oujda, MAR.
Department of Neonatology and Neonatal Intensive Care, University Hospital Center of Mohammed VI, Faculty of Medicine and Pharmacy, Mohammed Premier University, Oujda, MAR.
Cureus. 2025 Jul 21;17(7):e88441. doi: 10.7759/cureus.88441. eCollection 2025 Jul.
This retrospective study conducted at the Mohammed VI University Hospital Center in Oujda analyzed clinically visible congenital malformations among neonates admitted over a one-year period. The maternal age profile predominantly included young adults, with a significant proportion of cases linked to consanguinity, highlighting a potential genetic contribution to the occurrence of these anomalies. Most malformations were diagnosed after birth, with congenital heart defects representing the most frequent anomaly, followed by major digestive malformations such as anal atresia and omphalocele. Cases involving multiple malformations were also documented. The neonatal outcomes revealed a concerning mortality rate, reflecting the severity of these congenital conditions. These findings emphasize the urgent need to strengthen prenatal screening programs, implement a national registry for congenital malformations, and enhance public health interventions focused on prevention and early diagnosis to improve neonatal prognosis and reduce morbidity and mortality in this region.
这项在乌季达的穆罕默德六世大学医院中心进行的回顾性研究，分析了在一年时间里收治的新生儿中临床可见的先天性畸形情况。产妇年龄分布主要以年轻人为主，相当一部分病例与近亲结婚有关，这凸显了这些异常情况发生的潜在遗传因素。大多数畸形在出生后被诊断出来，先天性心脏缺陷是最常见的畸形，其次是诸如肛门闭锁和脐膨出等主要消化器官畸形。也记录了涉及多种畸形的病例。新生儿结局显示出令人担忧的死亡率，反映出这些先天性疾病的严重性。这些发现强调了迫切需要加强产前筛查项目，建立全国先天性畸形登记系统，并加强以预防和早期诊断为重点的公共卫生干预措施，以改善该地区新生儿的预后并降低发病率和死亡率。
