Almeida Ricardo, Bicudo Luiza, Felipe Leika, Andrade de Paulo Gustavo, Maluf-Filho Fauze, Lenz Luciano
Hospital São Cristóvão, São Paulo, Brazil.
Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
ACG Case Rep J. 2025 Aug 21;12(8):e01784. doi: 10.14309/crj.0000000000001784. eCollection 2025 Aug.
Vulvar melanoma (VM) is a rare and aggressive malignancy with a high metastatic potential. We present the case of an 82-year-old woman who initially presented with vaginal bleeding and was diagnosed with VM with lymph node involvement. Despite surgical and palliative interventions, she later developed brain, nodal, and pancreatic metastases. Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) confirmed pancreatic metastasis through immunohistochemistry. To our knowledge, this is the first reported case of pancreatic metastasis from VM diagnosed by EUS-FNB. This case highlights the importance of EUS-FNB in diagnosing metastatic lesions in unusual locations.
外阴黑色素瘤（VM）是一种罕见且侵袭性强、具有高转移潜能的恶性肿瘤。我们报告了一例82岁女性病例，该患者最初表现为阴道出血，被诊断为伴有淋巴结受累的VM。尽管进行了手术和姑息性干预，但她后来出现了脑、淋巴结和胰腺转移。内镜超声引导下细针穿刺活检（EUS-FNB）通过免疫组化证实了胰腺转移。据我们所知，这是首例通过EUS-FNB诊断出的VM胰腺转移病例。该病例凸显了EUS-FNB在诊断非寻常部位转移病灶方面的重要性。
