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针对噬菌体的:挑战与机遇

Bacteriophages against : challenges and opportunities.

作者信息

Segundo-Arizmendi Nalleyt, Flores-Coria Alejandra Paola, Gómez-Garcia Janeth, Hernández-Baltazar Efrén, Meneses-Acosta Angélica

机构信息

Laboratory 9: Microbiology and Parasitology, Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, Mexico.

Laboratory 3: Research Lab, Latinamerican University, Cuernavaca, Morelos, México.

出版信息

Front Bioeng Biotechnol. 2025 Aug 7;13:1605263. doi: 10.3389/fbioe.2025.1605263. eCollection 2025.

Abstract

is the most common pathogen transmitted to humans through contaminated water and food. Due to its ability to infect both animals and humans, as well as the spread of antibiotic-resistant strains, this pathogen has become a priority for food and pharmaceutical industries. Consequently, research and development of treatments to combat infections caused by are ongoing. One of the most promising strategies is the phage therapy (PT) which is based on the use of very specific viruses that infect this pathogenic bacterium without any action over the host and which use has shown effectiveness. Now a days, at least 41 companies worldwide market phage therapy products mainly for use in the food sector to reduce the transmission chain of to humans. However, the complex production processes required to ensure product quality, stability, safety, and efficacy, as well as the need for regulatory frameworks for phage therapy, present limitations to the global application of this strategy seems to be a limitation to promote its use all over the world as a pharmaceutical product. Thus, this work presents a literature review on state-of-the-art of PT, analysing the opportunities and challenges that are present to consider such a therapy as an emerging treatment for antibiotic resistance of

摘要

是通过受污染的水和食物传播给人类的最常见病原体。由于其能够感染动物和人类,以及抗生素耐药菌株的传播,这种病原体已成为食品和制药行业的优先关注对象。因此,对抗由其引起的感染的治疗方法的研发工作正在进行。最有前景的策略之一是噬菌体疗法(PT),该疗法基于使用非常特异性的病毒,这些病毒可感染这种致病细菌而对宿主无任何作用,并且其使用已显示出有效性。如今,全球至少有41家公司销售噬菌体疗法产品,主要用于食品领域,以减少其向人类的传播链。然而,确保产品质量、稳定性、安全性和有效性所需的复杂生产过程,以及噬菌体疗法监管框架的需求,对该策略在全球的应用构成了限制,这似乎是将其作为药品在全球推广使用的一个限制。因此,这项工作对噬菌体疗法的最新技术进行了文献综述,分析了将这种疗法视为抗生素耐药性新兴治疗方法所面临的机遇和挑战

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4d/12369589/ad4f81befe46/fbioe-13-1605263-g001.jpg

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