Naserghandi Alvand, Abedi Amir Reza, Tofighi Zavareh Mohammad Amin, Shahsavari Mohammad Javad, Shadravan Mohammad Mehdi, Mirzaei Soroush, Kakaee Mohamad Amir, Allameh Farzad
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2025 Jun 9;16:e16. doi: 10.34172/jlms.2025.16. eCollection 2025.
Prostate cancer is the second most prevalent cancer in men and remains a major global health concern. Traditional treatment modalities such as radical prostatectomy (RP) and radiation therapy, while effective, often result in significant morbidity, including urinary incontinence and sexual dysfunction. A narrative review was conducted to synthesize current evidence on focal laser therapy for prostate cancer. A comprehensive literature search was performed across three major databases: PubMed, Scopus, and Web of Science. The search strategy employed the following Medical Subject Headings (MeSH) terms and keywords: ("Prostatic Neoplasms" [MeSH] OR "prostate cancer") AND ("Laser Therapy" [MeSH] OR "laser ablation" OR "focal therapy"). The search was limited to studies published between 2000 and 2024. The initial search retrieved 1,444 articles. After a rigorous screening of titles, abstracts, and full-texts, 79 studies met the inclusion criteria and were incorporated into the review. The selected literature enables a comprehensive and critical evaluation of the current state of research on focal laser therapy in the management of prostate cancer. While focal laser therapies offer promising outcomes with fewer side effects, their long-term efficacy and survival benefits remain uncertain. High-quality studies with long-term follow-up are essential to better define their role in the prostate cancer treatment landscape and inform optimal patient selection.
前列腺癌是男性中第二常见的癌症，仍然是全球主要的健康问题。传统的治疗方式，如根治性前列腺切除术（RP）和放射治疗，虽然有效，但往往会导致严重的并发症，包括尿失禁和性功能障碍。进行了一项叙述性综述，以综合目前关于前列腺癌聚焦激光治疗的证据。在三个主要数据库——PubMed、Scopus和Web of Science中进行了全面的文献检索。检索策略采用了以下医学主题词（MeSH）术语和关键词：（“前列腺肿瘤”[MeSH]或“前列腺癌”）以及（“激光疗法”[MeSH]或“激光消融”或“聚焦疗法”）。检索仅限于2000年至2024年发表的研究。初步检索获得了1444篇文章。经过对标题、摘要和全文的严格筛选，79项研究符合纳入标准并被纳入综述。所选文献有助于对前列腺癌管理中聚焦激光治疗的当前研究状况进行全面和批判性评估。虽然聚焦激光疗法具有副作用较少的良好前景，但其长期疗效和生存益处仍不确定。高质量的长期随访研究对于更好地确定其在前列腺癌治疗格局中的作用并为最佳患者选择提供依据至关重要。
